Evidence map›Paper›PMID 40820345›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Sex differences in the impact of genetic and clinical risk factors for Alzheimer's disease in midlife.

Kyoko Konishi, Dylan S Spets, Paris Fisher, Sarah Aroner, Sarah M Sant, Dmitry Prokopenko, Hrishikesh Lokhande, Rohit Patel, Harlyn Aizley, Brianna Smith and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Kyoko KonishiDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Dylan S SpetsDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Paris FisherDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sarah AronerDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sarah M SantDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Dmitry ProkopenkoInnovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hrishikesh LokhandeDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rohit PatelDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harlyn AizleyDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Brianna SmithDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Anne RemingtonDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Emma SpoonerDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alexandra TouroutoglouDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jonathan RosandInnovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA.
Steven ArnoldInnovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hang LeeBiostatistics Center, Massachusetts General Hospital, Boston, MA, USA.
Bradford DickersonDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Rudolph E TanziInnovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA.
Tanuja ChitnisInnovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jill M GoldsteinDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1689-7791

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Hormones/Genes in Women's Health: From Bench to BedsideK12HD051959 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, REXRODE, KATHRYN M · 2005 to 2023
$8.8M
Impact of Depression on Alzheimer's disease: Prenatal Immune Origins and Shared Impact of SexR01AG067019 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GOLDSTEIN, JILL M · 2019 to 2023
$7.2M
Hormones and Genes in Women's Health: From Bench to BedsideK12AR084230 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI JILL M GOLDSTEIN, KATHRYN M REXRODE · 2023 to 2026
$2.6M
Impact of sex differences in immune function on shared risk for cardiometabolic disorder & Alzheimer's diseaseR01AG074008 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GOLDSTEIN, JILL M · 2024 to 2025
$2.5M
Sex Differences in Alzheimer's disease-Related Pathology: Role of Mitochondrial Function and Metabolic HealthK01AG081500 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kyoko Konishi · 2023 to 2026
$514k
NCATS NIH HHS UL1 TR002541NIAMS NIH HHS K12 AR084230NIA NIH HHS K01 AG081500NIA NIH HHS R01 AG067019NIA NIH HHS R01 AG074008NIBIB NIH HHS P41 EB015896NICHD NIH HHS K12 HD051959
6 · The paper itself

Abstract

BackgroundPreclinical risk for Alzheimer's disease (AD), including amyloid-β (Aβ) deposition, begins 10-15 years prior to diagnosis. In addition to genetics, hypertension, type 2 diabetes, and depression in midlife are major risk factors for AD.ObjectiveHere, we assessed sex differences in associations of AD risk status with memory circuitry function and AD pathology in midlife.MethodsHigh- (HR) and low-risk (LR) participants (N = 99; ages 52-71 years) were recruited from the Mass General Brigham Biobank. HR participants have genetic risk (

Indexed as

Alzheimer DiseaseSex CharacteristicsAgedAmyloid beta-PeptidesApolipoprotein E4BrainDiabetes Mellitus, Type 2FemaleHumansHypertensionMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPositron-Emission TomographyRisk FactorsAmyloid beta-PeptidesApolipoprotein E4Alzheimer's diseaseamyloid-βAPOE4fMRImemoryPETsex differences

Identifiers

PMID40820345
PMCPMC12979647

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.