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Association of hemodynamic and functional variables with pulmonary vasculopathy in lung transplant recipients living at high altitude: A retrospective study.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Hemodynamic and Thrombotic Vulnerability in Pulmonary Arterial Hypertension at High Altitude: Multivariable Predictors of Mortality.Medicina (Kaunas, Lithuania) · 2026Article
- Increased Right Ventricular Cardiac Output to Left Ventricular Cardiac Output Ratio in High-Altitude Residents Without Pulmonary Hypertension: An Echocardiography Study.Physiological research · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectivePulmonary hypertension is a heterogeneous syndrome with diverse underlying etiologies. This study aimed to evaluate the association between preoperative hemodynamic parameters-assessed by right heart catheterization (RHC) and transthoracic echocardiography (TTE)-and histopathological findings in explanted lungs from transplant recipients residing at high altitude.MethodsWe conducted a retrospective analysis of lung transplant recipients with interstitial lung disease (ILD) who had available RHC and TTE data prior to transplantation. Clinical, functional, hemodynamic, and histopathological variables were collected to assess the presence and severity of pulmonary vasculopathy. Bivariate analyses, correlation tests, and internally validated predictive models were performed to explore these associations.ResultsA total of 38 patients were included (median age: 54 years). The median mean pulmonary artery pressure (mPAP) was 33 mmHg, and the pulmonary artery systolic pressure (PASP) was 42 mmHg. An inverse correlation was observed between vasculopathy grade and the ratio of tricuspid annular plane systolic excursion to PASP (TAPSE/PASP) (
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