Evidence map›Paper›PMID 40820233›Full record

ArticlePediatric dermatology

Comparing Pediatric Dermatology Research Funded by the US National Institutes of Health (NIH) With the US Skin Disease Burden in Patients Under 20 Years Old.

Elyse Mackenzie, Nishita Amancharla, Stephanie Casagrande, Waasae Ayyaz, Madeline Tchack, Noah Musolff, Babar Rao

Abstract readComparative Study
In one paragraph

Article in Pediatric dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elyse MackenzieRutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.ORCID https://orcid.org/0009-0004-0432-6849
Nishita AmancharlaRutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
Stephanie CasagrandeRutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
Waasae AyyazRutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
Madeline TchackRutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.ORCID https://orcid.org/0009-0009-7544-0418
Noah MusolffRao Dermatology, New York, New York, USA.ORCID https://orcid.org/0009-0003-6952-0661
Babar RaoRao Dermatology, New York, New York, USA.ORCID https://orcid.org/0000-0002-9638-1279

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisease burden, measured by disability-adjusted life years (DALYs), is a helpful metric to guide research funding priorities. Pediatric dermatologic conditions significantly contribute to DALYs, yet it is unclear whether NIH funding reflects this burden.

objectivesTo compare NIH-funded dermatology research with the most burdensome skin diseases in the United States for patients under 20 years old, as measured by DALYs, and to identify mismatches between funding and disease burden.

methodsA cross-sectional analysis was independently performed by two researchers who matched projects from the 2024 to 2025 NIH Research Portfolio Online Reporting Tools with 10 pediatric dermatology skin conditions and their respective DALYs from the Global Burden of Disease (GBD) 2021 study. NIH-funded research projects were categorized by condition and pediatric focus, and funding allocation was compared to DALYs to evaluate alignment.

resultsThe NIH supported 307 grants totaling $388 million across the 10 skin conditions. Atopic dermatitis received the most funding ($62.99 million), with 47.9% of grants pediatric-focused. Viral skin diseases, despite being second in burden, received only $2.35 million and 0 pediatric grants. Most conditions had fewer than 15% pediatric-focused grants.

conclusionsThere is a persistent mismatch between NIH funding and the burden of pediatric skin disease, both in overall funding and in the proportion of research focused on pediatric populations. Increased investment in high-burden, underfunded conditions, particularly those lacking pediatric-specific research, is essential.

Indexed as

Biomedical ResearchCost of IllnessDermatologyNational Institutes of Health (U.S.)Research Support as TopicSkin DiseasesAdolescentChildChild, PreschoolCross-Sectional StudiesDisability-Adjusted Life YearsHumansInfantMaleUnited StatesYoung Adult

Identifiers

PMID40820233
PMCPMC12459415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.