Evidence map›Paper›PMID 40820199›Full record

ArticleBMC psychology2025

Psychological flexibility mediates the long-term impact of adverse interpersonal experiences in childhood and adolescence.

Leonardo Fazio, Cristina Semeraro, Teresa Claudia Pennacchio, Martina Grazia Asselti, Marianna Russo, Rosalinda Cassibba, Alessandro Bertolino, Antonio Rampino, Ignazio Grattagliano, Giulio Pergola and 1 more

Abstract read
In one paragraph

Article in BMC psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leonardo FazioDepartment of Medicine and Surgery, LUM University - Casamassima (Bari), Bari, Italy.
Cristina SemeraroDepartment of Education, Psychology, Communication, University of Bari Aldo Moro, Bari, Italy.
Teresa Claudia PennacchioDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Martina Grazia AsseltiDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Marianna RussoDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Rosalinda CassibbaDepartment of Education, Psychology, Communication, University of Bari Aldo Moro, Bari, Italy.
Alessandro BertolinoDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Antonio RampinoDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Ignazio GrattaglianoDepartment of Education, Psychology, Communication, University of Bari Aldo Moro, Bari, Italy.
Giulio PergolaDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy. giulio.pergola@uniba.it.
Linda Antonella AntonucciDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy. linda.antonucci@uniba.it.

Funding

Complementary National Plan PNC "Research initiatives for innovative technologies and pathways in the health and welfare sector" 2022 CUPB53C22006420001The Italian Ministry for Universities and Research (MUR) - Horizon Europe Seeds 2021 CUP H99J21017550006The Italian Ministry for Universities and Research (MUR) - Research Projects of National Relevance (PRIN) 2020 CUP H95F21001830001The Italian Ministry for Universities and Research (MUR) - Research Projects of National Relevance (PRIN) 2022 CUP H53D23004250006
6 · The paper itself

Abstract

backgroundEarly exposure to interpersonal adverse events, such as traumatic childhood events or exposure to bullying, abuse, or harassment, can impact an adult's psychological functioning. The negative effects on quality of life and the increased risk of psychopathological outcomes may underscore long-lasting vulnerabilities. Psychological flexibility is defined as the ability to be present in the moment and to pursue one's values, and it can facilitate coping with adverse events occurring in the present. An open question is whether psychological flexibility may contribute to reducing the long-term consequences of exposure to early adversities. The relevance of this research is that psychological flexibility is modifiable through intervention. The present study investigated the potential role of psychological flexibility in modulating the relationship between early exposure to interpersonal adverse events and two outcomes in young adults: quality of life and psychological symptomatology.

methodsWe recruited one hundred and nine women aged 19-21 years. Exposure to adverse interpersonal events was assessed with the Childhood Trauma Questionnaire and the Bullying Scale; quality of life and psychological symptomatology were measured with the World Health Organization Quality of Life Scale and the Symptom checklist-90, respectively; psychological flexibility was assessed with the Multidimensional Psychological Flexibility Inventory.

resultsThe frequency of adverse interpersonal events was associated with lower quality of life and greater psychological symptoms. Psychological flexibility mediated the relationship between the frequency of interpersonal adverse events and measures of quality of life, with an indirect effect explaining 18-42% of the total effect. Similarly, psychological flexibility mediated between the frequency of interpersonal adverse events and psychological symptomatology, with an indirect effect explaining 21-22% of the total effect.

conclusionThe present study evaluates the impact of exposure to interpersonal adverse events on different aspects of quality of life and psychological symptomatology. The results suggest that psychological flexibility mediates the long-term repercussions of interpersonal adversity. As psychological flexibility is a modifiable skill, interventions aimed at enhancing it in individuals with early exposure to adverse interpersonal events, such as traumatic childhood events, bullying, abuse, or harassment, could be used to reduce the long-term effects of past adversities.

Indexed as

Adaptation, PsychologicalAdverse Childhood ExperiencesInterpersonal RelationsQuality of LifeAdolescentBullyingChildFemaleHumansSurveys and QuestionnairesYoung AdultAcceptance and commitment therapyACEAdverse childhood experienceBullyingBullying victimizationChildhood traumaClinical psychologyPsychological flexibilityPsyc hopathologyQuality of life

Identifiers

PMID40820199
PMCPMC12360030

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.