Evidence map›Paper›PMID 40820181›Full record

ArticleLifetime data analysis2025

Causal effect estimation on restricted mean survival time under case-cohort design via propensity score stratification.

Wei-En Lu, Ai Ni

Abstract read
In one paragraph

Article in Lifetime data analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wei-En LuDivision of Biostatistics, College of Public Health,Ohio State University, Columbus, USA.
Ai NiDivision of Biostatistics, College of Public Health,Ohio State University, Columbus, USA. ni.304@osu.edu.ORCID 0000-0003-3002-3556

Funding

COMMUNITY AND COHORT SURVEILLANCE PROGRAMS-N01HC55015N01HC055015 · HC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI CHAMBLESS, LLOYD E · 1985 to 2006
$1.1M
COMMUNITY AND COHORT SURVEILLANCE PROGRAMN01HC055016 · HC · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE M · 1985 to 2000
$785k
FIELD CENTER FOR CCSPN01HC055019 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1985 to 2000
$748k
FIELD CENTERN01HC055021 · HC · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI JONES, DANIEL W · 1985 to 2000
$617k
CCSP-FIELD CENTERN01HC055020 · HC · JOHNS HOPKINS UNIVERSITY · PI NIETO, F JAVIER · 1985 to 2000
$334k
CENTRAL HEMOSTATIS LABORATORY FOR CCSPN01HC055022 · HC · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WU, KENNETH K · 1985 to 2000
$264k
Matched Design with Sensitivity Analysis for Observational Survival Data in Cardiovascular Patient Management using EMR DataR21HL170212 · NHLBI · OHIO STATE UNIVERSITY · PI LU, BO · 2023 to 2024
$231k
CCSP--FIELD CENTER AND ULTRASOUND READING CENTERN01HC055018 · HC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI HEISS, GERARDO · 1985 to 2000
$104k
NHLBI NIH HHS 1R21HL170212NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS R21 HL170212
6 · The paper itself

Abstract

In large observational studies with survival outcome and low event rates, the case-cohort design is commonly used to reduce the cost associated with covariate measurement. The restricted mean survival time (RMST) difference has been increasingly used as an alternative to hazard ratio when estimating the causal effect on survival outcomes. We investigate the estimation of marginal causal effect on RMST under the stratified case-cohort design while adjusting for measured confounders through propensity score stratification. The asymptotic normality of the estimator is established, and its variance formula is derived. Simulation studies are performed to evaluate the finite sample performance of the proposed method compared to several alternative methods. Finally, we apply the proposed method to the Atherosclerosis Risk in Communities study to estimate the marginal causal effect of high-sensitivity C-reactive protein level on coronary heart disease-free survival.

Indexed as

CausalityPropensity ScoreCohort StudiesComputer SimulationC-Reactive ProteinHumansProportional Hazards ModelsSurvival AnalysisC-Reactive ProteinARIC studyCausal effect estimationPropensity score stratificationRestricted mean survival timeStratified case-cohort designSurvival analysis

Identifiers

PMID40820181
PMCPMC12586416

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.