Evidence map›Paper›PMID 40820144›Full record

Trial reportScientific reports2025

Psychological inoculation improves resilience to and reduces willingness to share vaccine misinformation.

Ruth E Appel, Jon Roozenbeek, Rebecca Rayburn-Reeves, Melisa Basol, Jonathan Corbin, Josh Compton, Sander van der Linden

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Science and Videogames: From Scientific Dissemination to Knowledge Production.American journal of human biology : the official journal of the Human Biology Council · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruth E AppelDepartment of Communication, Stanford University, Stanford, USA.
Jon RoozenbeekDepartment of War Studies, King's College London, London, UK. jjr51@cam.ac.uk.
Rebecca Rayburn-ReevesCenter for Advanced Hindsight, Duke University, Durham, USA.
Melisa BasolDepartment of Psychology, University of Cambridge, Cambridge, UK.
Jonathan CorbinCenter for Advanced Hindsight, Duke University, Durham, USA.
Josh ComptonSpeech at Dartmouth, Dartmouth College, Hanover, USA.
Sander van der LindenDepartment of Psychology, University of Cambridge, Cambridge, UK.

Funding

British Academy PF21/210010Cabinet Office of the United Kingdom #SCH-00001-3391CDC HHS #6NU87PS004366-03-02Horizon 2020 964728
6 · The paper itself

Abstract

Vaccine misinformation endangers public health by contributing to reduced vaccine uptake. We developed a short online game to reduce people's susceptibility to vaccine misinformation. Building on inoculation theory, the Bad Vaxx game exposes people to weakened doses of manipulation techniques commonly used in vaccine misinformation and to strategies to identify these techniques. Across three preregistered randomized controlled trials (N = 2,326), we find that the game significantly improves participants' ability to discern vaccine misinformation from non-misinformation, their confidence in their ability to do so, and the quality of their sharing decisions. Further, taking the perspective of a character fighting as opposed to spreading misinformation is more effective on some outcome measures. In line with the learning goals of the intervention, we show that participants improve their ability to correctly identify the use of specific misinformation techniques. This insight is important because teaching manipulation technique recognition is not only effective to help evaluate information about vaccines, but also more viable than trying to debunk myriads of constantly-evolving myths. Our findings suggest that a short, low-cost, gamified intervention can increase resilience to vaccine misinformation.

Indexed as

CommunicationVaccinationVaccination HesitancyVaccinesAdultFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedYoung AdultVaccinesGamificationInoculation theoryMisinformationTechnique recognitionVaccine

Identifiers

PMID40820144
PMCPMC12358572

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.