Evidence map›Paper›PMID 40820061›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Synthesis and characterization of indole-3-butyric acid-based hydrazones: from multifunctional enzyme inhibition to therapeutic potential for drug development.

Sehar Madni, Muhammad Sajid Hamid Akash, Shagufta Kamal

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sehar MadniDepartment of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
Muhammad Sajid Hamid AkashDepartment of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan. sajidakash@gcuf.edu.pk.
Shagufta KamalDepartment of Biochemistry, Government College University, Faisalabad, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study explores the synthesis, spectroscopic characterization, and biological profiling of indole-3-butyric acid-derived hydrazones, notably 1-(4-amino-3,5dichlorophenyl) ethylidene-4-indol-3-butanehydrazide hydrazone and 4-indole-3-butane-(thiophen-2-ylmethylene) hydrazide hydrazone. The structural integrity of the synthesized compounds was confirmed by UV-Vis spectroscopy, FTIR, EI-MS, and

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsCholinesterase InhibitorsHydrazonesIndolesAcetylcholinesterasealpha-AmylasesAntioxidantsCell Line, TumorDrug DevelopmentHumansMolecular Docking SimulationStructure-Activity RelationshipAcetylcholinesterasealpha-AmylasesAnti-Bacterial AgentsAntineoplastic AgentsAntioxidantsCholinesterase InhibitorsHydrazonesIndolesADMETAnticancerBioactivityEnzyme inhibitionHydrazonesIndole-3-butyric acidMolecular dynamics

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.