Evidence map›Paper›PMID 40820060›Full record

ReviewJournal of the Egyptian National Cancer Institute2025

Inducer microRNAs in the glioma development: a concise review of mechanisms and insights into targeted therapy.

Mahya Pourrahimi, Marjan Hesari, Hannaneh Houshmandpour, Omid Mirzaee, Hamed Fouladseresht, Ensiye Torki, Hosein Kouchaki, Reza Tabrizi, Abdolmajid Ghasemian, Silvia Barbaresi

Abstract readReview
In one paragraph

Review in Journal of the Egyptian National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mahya PourrahimiDepartment of Medical Sciences, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Marjan HesariBiomedicine Research Facility II, University of San Diego School of Medicine, San Diego, USA.
Hannaneh HoushmandpourDepartment of Medical Sciences, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Omid MirzaeeShiraz University of Medical Sciences, Shiraz, Iran.
Hamed FouladsereshtDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. fouladsereshtimmunology@gmail.com.
Ensiye TorkiDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Hosein KouchakiUSERN Office, Fasa University of Medical Sciences, Fasa, Iran.
Reza TabriziClinical Research Development Unit, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Iran.
Abdolmajid GhasemianNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. majidghasemian86@gmail.com.ORCID http://orcid.org/0000-0002-1243-6341
Silvia BarbaresiDepartment of Movement and Sports Sciences, Ghent University, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gliomas represent predominant and fatal central nervous system (CNS) cancers lacking a gold standard of treatment, which need accurate prognosis, diagnosis, and intervention. Glioma accurate therapy using common traditional approaches such as surgical treatment, radiotherapy, and chemotherapy results insufficient mainly due to side effects, recurrence, and resistance. Scientific and medical challenges can be decreased considering novel therapeutic targets. The multiple and diverse role of microRNAs (miRNAs) in cellular processes has been demonstrated. The appreciation of miRNAs regulatory roles in cancer cell proliferation or growth inhibition opens new perspectives in the development of novel strategies targeting cancers. Six inducers (miRNAs) including miR-363-3P, miR720, miR-484, miR-890, miR-496, and miR-939-5p can develop into glioma cells with the potential of therapeutic targets. Therefore, the tracking of glioma stage and response to anticancer therapy is associated with various miRNAs. The objective of this review is to provide a comprehensive assessment of the role of miRNAs in glioma cancer development.

Indexed as

Brain NeoplasmsGliomaMicroRNAsBiomarkers, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMolecular Targeted TherapyBiomarkers, TumorMicroRNAsBiomarkersCancer therapyDiagnosisGliomaMicroRNAs

Identifiers

PMID40820060
PMCPMC13313405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.