Evidence map›Paper›PMID 40820028›Full record

ArticleScientific reports2025

Inflammatory mediation by neutrophil percentage to albumin ratio in the association between chronic kidney disease and presbycusis.

Qingling Wang, Ruizhe Huang, Shiduo Guo, Zhenju Xu, Yichuan Huang, Dapeng Liang, Xiangdong Guo, Liwei Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qingling WangDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Ruizhe HuangThe First Clinical College, Changsha Medical University, Changsha, China.
Shiduo GuoDepartment of Hepatobiliary Surgery, Qingdao Jimo People's Hospital, Qingdao, Shandong, China.
Zhenju XuDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yichuan HuangDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Dapeng LiangDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xiangdong GuoDepartment of Otolaryngology, the First Affiliated Hospital of Henan Traditional Chinese Medical College, Zhengzhou, China. guoxiangdong0618@126.com.
Liwei JiangDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. jiangliwei@qdu.edu.cn.

Funding

the Henan Provincial Science and Technology Research Project. 24A360007Youth Science Fund Project of National Natural Science Foundation of China 81403439
6 · The paper itself

Abstract

This study assessed the association between chronic kidney disease (CKD) and presbycusis and investigated whether inflammatory neutrophil percentage-to-albumin ratio (NPAR) indicators influence this relationship. This study used data from the National Health and Nutrition Examination Survey and employed methods such as restricted cubic spline analysis, multiple logistic regression analyses, and mediation analyses to explore these relationships. High-frequency hearing impairment (HI) was correlated with moderate CKD (OR = 3.25, 95% CI:1.25- 8.46, P = 0.02). HI grades were correlated with moderate CKD [for slight HI, (OR = 5.13, 95% CI:1.48- 17.86, P = 0.01); for moderate and severe HI, (OR = 4.68, 95% CI:1.29 -17.04, P = 0.02)]. Mediation analysis revealed that NPAR had a 17.85% mediating effect on the association between moderate CKD and presbycusis. Moderate CKD was associated with high-frequency HI in the elderly, and NPAR had a significant mediating effect on this relationship.

Indexed as

InflammationNeutrophilsPresbycusisRenal Insufficiency, ChronicSerum AlbuminAgedFemaleHumansMaleMiddle AgedNutrition SurveysSerum AlbuminChronic kidney diseaseInflammatory biomarkerNeutrophil-percentage-to-albumin ratioPopulation basedPresbycusis

Identifiers

PMID40820028
PMCPMC12358530

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.