Evidence map›Paper›PMID 40820014›Full record

ArticleScientific reports2025

Dendrobium officinale Kimura & Migo polysaccharide ameliorates skin photoaging by promoting angiogenesis.

Yan Long, Yuanmin Zhang, Yumeng Dong, Yibo Hu, Ling Jiang, Chuhan Fu, Jing Chen, Li Lei, Qinghai Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan Long *Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Yuanmin Zhang *Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Yumeng DongDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Yibo HuDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Ling JiangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Chuhan FuDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Jing ChenDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. 43700351@qq.com.
Li LeiDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. 676747867@qq.com.
Qinghai ZengDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. zengqinghai@csu.edu.cn.

Funding

High-level Health Talents in Hunan Province 20240304082Natural Science Foundation of Hunan Province 2022JJ30880Natural Science Foundation of Hunan Province 2023JJ20091Scientific Research Program of Hunan Provincial Health Commission B202304127273the "co-PI" project from The Third Xiangya Hospital of Central South University Number: 202412the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University YX202007
6 · The paper itself

Abstract

Dendrobium officinale Kimura & Migo polysaccharide (DOP) is one of the main bioactive components of traditional Chinese medicine. Although DOP can encourage the growth of blood vessels surrounding hair follicles, it is unknown if it can ameliorate skin photoaging by stimulating angiogenesis. This study used publicly available data sets. Analysis of GSE38308 and GSE274955 data sets showed impaired angiogenesis in photoaged skin. In the ultraviolet (UV) radiation-induced photoaging model of Kunming mice, local DOP administration was found to enhance skin elasticity, increase collagen levels, promote angiogenesis, and demonstrate therapeutic potential for ameliorating photoaging in mice. In the UVB-induced photoaging model of human umbilical vein endothelial cells (HUVEC), UVB radiation induced cellular senescence and reduced the tube-forming capacity of HUVECs, whereas DOP treatment was found to enhance angiogenesis by activating the kinase insert domain receptor (KDR)/phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway, thereby ameliorating photoaging. These findings provide a novel mechanism for the amelioration of skin photoaging by DOP, highlighting its potential as a therapeutic agent for treating skin photoaging.

Indexed as

DendrobiumNeovascularization, PhysiologicPolysaccharidesSkin AgingAngiogenesisAnimalsCellular SenescenceHumansHuman Umbilical Vein Endothelial CellsMiceProto-Oncogene Proteins c-aktSignal TransductionSkinUltraviolet RaysPolysaccharidesProto-Oncogene Proteins c-aktAngiogenesisDendrobium officinale Kimura & Migo polysaccharidePI3K-Akt signaling pathwaySkin photoaging

Identifiers

PMID40820014
PMCPMC12358527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.