ArticleGastroenterology2026
Histologic Response Is Associated With Improved Esophageal Distensibility and Symptom Burden in Pediatric Eosinophilic Esophagitis.
Article in Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Beyond the Surface: Exploring Altered Esophageal Distensibility and Compliance in Eosinophilic Esophagitis.Digestive diseases and sciences · 2026Review
- Pediatric Esophageal Biomechanics and Remodeling: Integrating Distensibility and Compliance Beyond Luminal Diameter.Journal of gastroenterology and hepatology · 2026Review
- Eosinophilic esophagitis: An aerodigestive perspective.Journal of pediatric gastroenterology and nutrition · 2026Review
- Review
- Overlapping type 2, barrier, and remodeling endotypes shape clinical expression in eosinophilic esophagitis.Frontiers in immunology · 2026Review
- Emerging Insights into the Inflammatory Phenotypes of Eosinophilic Esophagitis.Journal of inflammation research · 2026Review
- Saccharin Aggravates Eosinophilic Esophagitis via MAPK3 Interaction: A Network Toxicology and Machine Learning Study With SPR Analysis.Food science & nutrition · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
BACKGROUND &
aimsChronic eosinophilic esophagitis (EoE)-associated inflammation can lead to progressive tissue remodeling and fibrostenosis. Longitudinal studies are limited, and the impact of histologic disease control during childhood remains unknown. The aim of this study was to evaluate the relationship between esophageal distensibility, histology, and fibrostenotic complications in a cohort of children with EoE.
methodsWe conducted a prospective longitudinal study at 2 tertiary pediatric institutions to evaluate longitudinal changes in esophageal distensibility in pediatric patients aged 3-18 years. Impedance planimetry was used to determine esophageal distensibility during the baseline endoscopy and all subsequent clinically necessary endoscopies. Symptomatic, endoscopic, and histologic data were collected at each visit.
resultsThree hundred endoscopies involving 112 patients with EoE (mean age, 12.8 years, 72.3% were male) were included, with a median follow-up time of 11 months (range, 2-54 months). Participants exhibiting a histologic response to treatment showed the most significant improvement in distensibility over time (1.41 vs 0.16-0.53 mm/y; P = .003). After adjusting for Eosinophilic Esophagitis Endoscopic Reference Score and age at symptom onset, lower esophageal distensibility was independently associated with increased odds of patient-reported dysphagia (odds ratio, 0.85; 95% CI, 0.75-0.96; P = .008). Patients who developed clinical features of fibrostenosis were older at diagnosis (9.9 vs 6.7 years; P = .032), experienced longer disease duration (4.4 vs 2.4 years; P = .046), and had lower baseline esophageal distensibility (13.0 vs 14.9 mm; P = .012). Baseline distensibility predicted the need for future stricture dilation (area under the curve, 0.757; P = .0003).
conclusionsHistologic remission is associated with improved esophageal distensibility over time in pediatric patients with EoE. Baseline esophageal distensibility provides a quantitative marker of tissue remodeling and may help predict disease severity and fibrostenotic progression.
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