Evidence map›Paper›PMID 40819626›Full record

ArticleEuropean journal of radiology2025

Malignancy rate of lesions presenting as architectural distortion on DBT related to accompanied features, ultrasound findings, and BI-RADS density.

Jiejie Zhou, Xiao Chen, Qiao Li, Rui Li, Sijia Wen, Yong Pan, Yan-Lin Liu, Yang Zhang, Jeon-Hor Chen, Guo Quan Cao and 2 more

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Article in European journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Jiejie ZhouDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Department of Radiological Sciences, University of California, Irvine, CA, United States.
Xiao ChenDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Qiao LiDepartment of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Rui LiDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Sijia WenDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yong PanDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yan-Lin LiuDepartment of Radiological Sciences, University of California, Irvine, CA, United States.
Yang ZhangDepartment of Radiological Sciences, University of California, Irvine, CA, United States.
Jeon-Hor ChenDepartment of Radiological Sciences, University of California, Irvine, CA, United States.
Guo Quan CaoDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Meihao WangDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Intelligent Medical Imaging of Wenzhou, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: wzwmh@wmu.edu.cn.
Min-Ying SuDepartment of Radiological Sciences, University of California, Irvine, CA, United States; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: msu@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

objectivesTo compare the malignancy rate of architectural distortion (AD) on DBT, shown as the prominent feature or as the associated feature coexisting with other significant radiological findings.

methods537 diagnostic patients who had symptoms or abnormal imaging findings were analyzed, 305 malignant and 232 benign. They were selected based on the original DBT report mentioning AD. Two fellowship-trained radiologists reviewed images and gave BI-RADS scores using a full range of 3-5, and determined whether the AD was the dominant feature or an associated feature. The original ultrasound (US) reports were reviewed to determine whether there were corresponding abnormalities and obtain the US BI-RADS scores for correlation with DBT results.

results230 cases were associated AD accompanying masses or highly suspicious microcalcifications, and the malignancy rate was 78 % (180/230). 307 cases were determined as the prominent AD with a significantly lower 41 % malignancy rate (125/307, p < 0.001). In the prominent AD group, the malignancy rate was 32/47 = 68 % when accompanied by intermediate-risk calcifications, 27/63 = 43 % with regional high-density, and 66/197 = 34 % in pure AD. Of them, 237 had corresponding US findings, and 70 cases did not, and the malignancy rate was 109/237 = 46 % vs. 16/70 = 23 %, higher when there were US correlates, p = 0.001.

conclusionAD shown on DBT may be accompanied by other radiological features related to mass, density, and different suspicious levels of microcalcifications, and the malignancy rates were different. Information from other supplementary imaging may help determine optimized management strategies.

Indexed as

Breast NeoplasmsMammographyUltrasonography, MammaryAdultAgedAged, 80 and overCalcinosisDiagnosis, DifferentialFemaleHumansMaleMiddle AgedReproducibility of ResultsSensitivity and SpecificityArchitectural distortionBI-RADSDBTTomosynthesis

Identifiers

PMID40819626
PMCPMC12753133

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