Evidence map›Paper›PMID 40819369›Full record

ArticleFuture medicinal chemistry2025

Synthesis, anti-biofilm and molecular docking of amino-substituted chalcones targeting

Mayara Aparecida Rocha Garcia, Mariana Bastos Dos Santos, Janaína de Cássia Orlandi Sardi, Ricardo André Zucato Bertani, Josy Goldoni Lazarini, Pedro Luiz Rosalen, Luis Octávio Regasini

Abstract read
In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mayara Aparecida Rocha GarciaDepartment of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University Júlio de Mesquita Filho, Sao Jose do Rio Preto, Brazil.
Mariana Bastos Dos SantosDepartment of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University Júlio de Mesquita Filho, Sao Jose do Rio Preto, Brazil.
Janaína de Cássia Orlandi SardiDepartment of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Ricardo André Zucato BertaniDepartment of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University Júlio de Mesquita Filho, Sao Jose do Rio Preto, Brazil.
Josy Goldoni LazariniDepartment of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Pedro Luiz RosalenDepartment of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Luis Octávio RegasiniDepartment of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University Júlio de Mesquita Filho, Sao Jose do Rio Preto, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance is an urgent global health challenge that requires the development of new antibacterial agents. In this study, 14 aminochalcones bearing electron-withdrawing groups were synthesized and evaluated for antibacterial activity. Chalcone

Indexed as

AminoacyltransferasesAnti-Bacterial AgentsBacterial ProteinsBiofilmsChalconesCysteine EndopeptidasesMolecular Docking SimulationStaphylococcus aureusAnimalsBacterial AdhesionHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAminoacyltransferasesAnti-Bacterial AgentsBacterial ProteinsChalconesCysteine Endopeptidasessortase AADMETantibacterialbiofilmChalconesmolecular dockingsortase Atoxicity

Identifiers

PMID40819369
PMCPMC12407658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.