Evidence map›Paper›PMID 40819368›Full record

ReviewNeurodegenerative disease management2026

Tremor management strategies in Parkinson's disease: optimizing patient care.

Nicola Pavese, David Ledingham

Abstract readReview
In one paragraph

Review in Neurodegenerative disease management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nicola PaveseTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
David LedinghamTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Along with bradykinesia and rigidity, tremor is one of the cardinal motor symptoms of Parkinson's disease (PD), often the first symptom to be noticed by the patient and their relatives. While bradykinesia and rigidity usually respond to dopaminergic therapies, tremor is often refractory to these medications and can cause significant disability in many patients. This variability of response appears to be related to different mechanisms/neurochemical abnormalities underlying the occurrence of tremor in PD patients.Here, we will discuss types of tremors in PD, the current understanding of the neurochemistry underlying Parkinsonian tremor, as possible targets for treatment, and the role of imaging and wearable devices to improve tremor management in these patients. We will summarize pharmacological strategies and more complex approaches, such as Deep Brain Stimulation and Magnetic Resonance guided Focussed Ultrasound, currently used in the management of PD patients with tremor. The role of non-pharmacological strategies will also be appraised.

Indexed as

Parkinson DiseaseTremorDeep Brain StimulationDisease ManagementHumansnon-pharmacological therapiesParkinson’ssurgical therapiestreatmenttremor

Identifiers

PMID40819368
PMCPMC12826704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.