ArticleBreast cancer research and treatment2025
High-resolution microCT to assess breast microcalcification morphometry by histologic lesion subtype and radiologic classification.
Article in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo assess associations of 3D morphometry of breast calcifications, determined using high-resolution microCT, with underlying histopathology and evaluate the potential for classifying tissue calcifications as an aid in optimizing identification and diagnosis of the most severe pathology in a biopsy.
methodsWe compared morphometry of calcifications in tissue blocks (n = 156) of benign breast disease (n = 74), ductal carcinoma in situ (n = 39), and ductal carcinoma in situ with invasive breast cancer (n = 43) using (10 µm) microCT. Matched sections were reviewed microscopically to define lesion(s) in which calcifications were embedded. 3D reconstructions of calcifications were reviewed independently by two masked radiologists to assess the need for biopsy and calcification morphology. Calcification morphometry was compared to pathologic diagnosis using linear mixed models.
resultsA total of 12,216 calcifications (IQR 9-66 per specimen) were analyzed. Individual breast cancer-associated calcifications were significantly larger than benign breast disease-associated calcifications (p
conclusionOur analysis provides proof-of-concept that morphometry of tissue calcifications varies by lesion type, suggesting that future studies may enable development of a pathologic classification linked to diagnosis and mammographic findings.
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