Evidence map›Paper›PMID 40819318›Full record

ArticlePediatric surgery international2025

Aggressive enema and surgery for meconium-related ileus in extremely low-birth-weight infants.

Kenji Santo, Yuichi Takama, Marie Todo, Hisashi Yagi, Shuto Ikeda, Yuko Tanaka, Hiroyuki Ichiba, Masafumi Kamiyama

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Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kenji SantoDepartment of Pediatric Surgery, Osaka City General Hospital, 2-13-22, Miyakojimahondori, Miyakojima-ku, Osaka, 534-0021, Japan. santokenji@gmail.com.
Yuichi TakamaDepartment of Pediatric Surgery, Osaka City General Hospital, 2-13-22, Miyakojimahondori, Miyakojima-ku, Osaka, 534-0021, Japan.
Marie TodoDepartment of Pediatric Surgery, Osaka City General Hospital, 2-13-22, Miyakojimahondori, Miyakojima-ku, Osaka, 534-0021, Japan.
Hisashi YagiDepartment of Pediatric Surgery, Osaka City General Hospital, 2-13-22, Miyakojimahondori, Miyakojima-ku, Osaka, 534-0021, Japan.
Shuto IkedaDepartment of Pediatric Surgery, Osaka City General Hospital, 2-13-22, Miyakojimahondori, Miyakojima-ku, Osaka, 534-0021, Japan.
Yuko TanakaDepartment of Neonatology, Osaka City General Hospital, Osaka, Japan.
Hiroyuki IchibaDepartment of Neonatology, Osaka City General Hospital, Osaka, Japan.
Masafumi KamiyamaDepartment of Pediatric Surgery, Osaka City General Hospital, 2-13-22, Miyakojimahondori, Miyakojima-ku, Osaka, 534-0021, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the effectiveness of an aggressive treatment strategy for meconium-related ileus (MRI) in extremely low birth weight infants (ELBWIs).

methodsSince April 2018, we have implemented a novel protocol, incorporating early Gastrografin injection, aggressive enema therapy, and early surgery without perforation (ES). Among 362 ELBWIs treated at our institute over the past 15 years, 91 with MRI were included in this study. We compared patient demographics, treatment details, and outcomes between the "Old" group (O, n = 56; treated before March 2018) and the "New" group (N, n = 35; treated after April 2018).

resultsThe O group showed higher perforation rates (21.4%; 12/56) than those of the N group (2.9%, 1/35) (p = 0.014). The surgical rates were 21.4% (12/56) and 14.3% (5/35) in the O and N groups, respectively (p = 0.581), while the ES rates were 0% (0/56) and 11.8% (4/35), respectively (p = 0.02). The N group had a significantly higher overall survival rate (100%, 35/35) than the O group (87.5%, 49/56) (p = 0.041). In the O group, all seven deaths were related to perforation.

conclusionsOur aggressive MRI treatment was associated with reduced perforation rates and improved survival outcomes, demonstrating its effectiveness.

Indexed as

EnemaInfant, Extremely Low Birth WeightMeconium IleusDiatrizoate MeglumineFemaleHumansInfant, NewbornIntestinal PerforationMaleRetrospective StudiesTreatment OutcomeDiatrizoate MeglumineEnemaExtremely low-birth-weightIleusInfantMeconiumNewborn

Identifiers

PMID40819318

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.