Evidence map›Paper›PMID 40819212›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Developing biobanking processes for Alzheimer's disease and related dementia research in Africa: Experience from the Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD-ADSP).

Kazeem Sanjo Akinwande, Patrice Whitehead, Samuel Diala, Motunrayo Coker, Larry Deon Adams, Mayowa Ogunronbi, Olayemi Balogun, Richard Boateng, Williams Kudzi, Ajibola Falayi and 63 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

73 authors.

Kazeem Sanjo AkinwandeNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.ORCID 0000-0002-1472-3344
Patrice WhiteheadJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Samuel DialaNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Motunrayo CokerNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Larry Deon AdamsJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Mayowa OgunronbiNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Olayemi BalogunDepartment of Medicine, Ahmadu Bello University, Zaria, Kaduna, Nigeria.
Richard BoatengDepartment of Medicine, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.
Williams KudziDepartment of Medicine, University of Ghana Medical School, Ghana//Korle Bu Teaching Hospital, Accra, Ghana.
Ajibola FalayiDepartment of Medicine, College of Medicine and Health Sciences, Afe Babalola University, Olusegun Obasanjo Way, Nigeria and Federal Teaching Hospital, Ido Ekiti, Ekiti, Nigeria.
Pascalyne Kavesa NyamaiAfrica Institute of Mental and Brain Health, Nairobi, Kenya.
Celia Filomena NovelaFaculty of Medicine, Eduardo Mondlane University, Hospital Central De Maputo, Maputo, Mozambique.
Tsehayneh KelemuCollege of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Jimoh Yemi AbdulraheemDivision of Neurology, Department of Medicine, University of Ilorin & University of Ilorin Teaching Hospital, Ilorin, Kwara, Nigeria.
Osimhiarherhuo AdeleyeDepartment of Chemical Pathology and Immunology, Federal Medical Centre Abeokuta, Abeokuta, Ogun State, Nigeria.
Roosevelt Amaobichukwu AnyanwuNeurology Unit, Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
Jedidiah AnkamahDepartment of Medicine, University of Ghana Medical School, Ghana//Korle Bu Teaching Hospital, Accra, Ghana.
Bamigbowu Olugbenga EmmanuelMedical Research Laboratory Unit, Department of Chemical Pathology, University of Port Harcourt, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers, Nigeria.
Lucius Chidiebere ImohDepartment of Medicine, University of Jos, Jos University Teaching Hospital, Jos, Plateau, Nigeria.
Wonder Agudey Doku-AgamaDepartment of Medicine, University of Ghana Medical School, Ghana//Korle Bu Teaching Hospital, Accra, Ghana.
Happiness KumburuDepartment of Medicine, Kilimanjaro Christian Medical College, Moshi, Tanzania.
Rogers KamulegeyaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Komolafe Benjamin IgeHaematology Department, Benue State University Teaching Hospital, Makurdi, Benue, Nigeria.
Olaolu Olajide FamuyiwaNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Gabriel OgundeNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Faith Chinaza EjimkonyeNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Joshua AkinyemiDepartment of Epidemiology and Medical Statistics, Faculty of Public Health, University of Ibadan, Ibadan, Oyo, Nigeria.
Mike CuccaroJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Pedro MenaJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Godwin OgboleDepartment of Radiology, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Olufisayo ElugbadeboDepartment of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Temitope FarombiTony Anenih Geriatric Center, University College Hospital, Ibadan, Oyo, Nigeria.
Michelle NicholsCollege of Nursing, Medical University of South Carolina, Charleston, South Carolina, USA.
Sunday AdeniyiDivision of Neurology, Department of Medicine, University of Ilorin & University of Ilorin Teaching Hospital, Ilorin, Kwara, Nigeria.
Mubashir UthmanDepartment of Epidemiology & Community Health, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin & University of Ilorin Teaching Hospital, Ilorin, Kwara, Nigeria.
Christine MusyimiAfrica Mental Health Research and Training Foundation, Nairobi, Kenya.
Victoria MutisoAfrica Mental Health Research and Training Foundation, Nairobi, Kenya.
Kolawole WahabDivision of Neurology, Department of Medicine, University of Ilorin & University of Ilorin Teaching Hospital, Ilorin, Kwara, Nigeria.
Godwin OsaigbovoDepartment of Medicine, University of Jos, Jos University Teaching Hospital, Jos, Plateau, Nigeria.
Ernest NwazorNeurology Unit, Department of Medicine, Rivers State University Teaching Hospital, Port Harcourt, Rivers, Nigeria.
Nosakhare OsemwegieMedical Research Laboratory Unit, Department of Chemical Pathology, University of Port Harcourt, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers, Nigeria.
Paul NwaniDepartment of Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra, Nigeria.
Adefolakemi Temitope OgundelePsychogeriatric Unit, Neuropsychiatric Hospital, Abeokuta, Ogun State, Nigeria.
Paul OlowoyoDepartment of Medicine, College of Medicine and Health Sciences, Afe Babalola University, Olusegun Obasanjo Way, Nigeria and Federal Teaching Hospital, Ido Ekiti, Ekiti, Nigeria.
Emmanuel Uzodinma IwuozoHaematology Department, Benue State University Teaching Hospital, Makurdi, Benue, Nigeria.
Damas Andrea MlakiDirectorate of Medical Services, Mirembe National Mental Health Hospital & University of Dodoma, Dodoma City, Tanzania.
Reginald ObiakoDepartment of Medicine, Ahmadu Bello University, Zaria, Kaduna, Nigeria.
Fred SarfoDepartment of Medicine, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.
Albert AkpaluDepartment of Medicine, University of Ghana Medical School, Ghana//Korle Bu Teaching Hospital, Accra, Ghana.
Thierry AdoukonouDepartment of Neurology, University of Parakou, Parakou, Benin.
Biniyam A AyeleCollege of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Yared ZenebeCollege of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Kamada LwereCollege of Health Sciences, Makerere University, Kampala, Uganda.
Albertino DamascenoFaculty of Medicine, Eduardo Mondlane University, Hospital Central De Maputo, Maputo, Mozambique.
Alfred K NjamnshiDepartment of Neurology, FMBS, The University of Yaoundé I, Yaounde & Brain Research Africa Initiative, Geneva, Switzerland, Yaoundé, Cameroon.
Judith BosheDepartment of Medicine, Kilimanjaro Christian Medical College, Moshi, Tanzania.
Stella-Maria PaddickTranslational and Clinical Research Institute, Newcastle University, UK/Gateshead Health NHS Foundation Trust, Gateshead, UK.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Jacob McCauleyJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Richard WalkerDepartment of Medicine, North Tyneside General Hospital, North Shields, Tyne and Wear, Rake Lane, UK.
Oyedunni ArulogunDepartment of Health Promotion and Education, Faculty of Public Health, University of Ibadan, Ibadan, Oyo, Nigeria.
Njideka OkubadejoNeurology Unit, Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
Olusegun BaiyewuDepartment of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Goldie ByrdMaya Angelou Centre for Health Equity, School of Medicine, Wake Forest University, Winston Salem, North Carolina, USA.
Mayowa OwolabiDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
David NdeteiAfrica Mental Health Research and Training Foundation, Nairobi, Kenya.
Brian W KunkleJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Anthony J GriswoldJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Rajesh N KalariaTranslational and Clinical Research Institute, Newcastle University, NIHR Biomedical Research Building, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.
Jeffery VanceJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Adesola OgunniyiDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Margaret Pericak-VanceJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Rufus AkinyemiNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.ORCID 0000-0001-5286-428X

Funding

Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)U19AG074865 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GOLDIE S. BYRD, William S Bush · 2022 to 2026
$55.3M
Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American AncestriesU01AG084545 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GOLDIE S. BYRD, ANTHONY JOHN GRISWOLD · 2024 to 2026
$14.9M
Global Brain Health Institute GBHI ALZ UK-21- 24204National Institute of AgingNIA NIH HHS U01 AG084545NIA NIH HHS U19 AG074865NIA NIH HHS U19AG074865
6 · The paper itself

Abstract

The Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD-ADSP) aims to recruit 5000 African participants (Alzheimer's disease [AD] and cognitively unimpaired controls) to generate genomic and biomarker data to better characterize AD neurobiology in Africa from countries that constitute the African Dementia Consortium (AfDC). Blood samples from study participants are separated into fractions and transported to the African Coordinating Centre (ACC: Ibadan, Nigeria), where DNA extraction and long-term biospecimen storage are carried out. Plasma and DNA aliquots are shipped to the John P. Hussman Institute for Human Genomics, University of Miami (HIHG-UM, Miami, USA) for genotyping, whole genome sequencing, and biomarker analysis. Innovative solutions were devised to mitigate challenges encountered so far. Our biobanking experience in a low-resource setting demonstrates the feasibility of establishing a successful African biobanking network, as an important infrastructure to support Alzheimer's disease and related dementias research in Africa. HIGHLIGHTS: Biobanking is gaining grounds in Africa in studies related to neurological disorders. The Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD-ADSP) biobanking network is a new initiative to enhance infrastructure for Alzheimer's disease and related dementias (ADRD) research in Africa through the African Dementia Consortium. The processes of the stepwise creation and development of the READD-ADSP biobanking network have been guided by global best practices and regulatory standards. Challenges were encountered in the process of establishing the READD-ADSP biobank, and home-grown solutions were developed to mitigate the challenges. The READD-ADSP biobanking experience offers lessons to researchers in low-resource settings on how collaborative efforts between the global north and global south enhance cutting-edge team science to tackle ageing-associated brain disorders in low- and middle-income countries.

Indexed as

Alzheimer DiseaseBiological Specimen BanksBiomedical ResearchDementiaPatient SelectionAfricaBiomarkersHumansBiomarkersAfrican Dementia ConsortiumAlzheimer's DiseaseBiobankingDementiaREADD‐ADSP

Identifiers

PMID40819212
PMCPMC12358004

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.