ArticleScientific reports2025
Analyzing the mechanism of rhubarb in the treatment of cervical cancer based on network pharmacology and molecular docking technology.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- LC-MS/MS-based metabolomics analysis and experimental verification reveal the mechanism of Dahuang Mudan Decoction inhibition with the proliferation of colorectal cancer cells.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Effects of fermentation byFood chemistry: X · 2026Article
- Crude Venom from Sea AnemoneMarine drugs · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
To investigate the mechanism of action of rhubarb in the treatment of cervical cancer by computer simulation techniques such as network pharmacology and molecular docking technology. The active ingredients of rhubarb were identified using TCMSP and HERB databases, and active ingredient target prediction was performed using SEA and Swiss TargetPrediction; cervical cancer-related targets were collected through four databases, namely, OMIM, GeneCards, CTD, and GDA; common targets of drugs and diseases were obtained through Draw Venn diagram; STRING online platform was applied to build protein-protein interaction networks (PPI) and core targets and most important modules were screened by cytoscape 3.10.3; use DAVID and REACTOM databases to perform GO functional enrichment analysis and KEGG pathway enrichment analysis, and visualize the results; Finally, molecular docking of key active ingredients and targets was performed by PubChem database and Auto Dock software, and the results were visualized by PyMOL. 23 active ingredients and 106 common targets were obtained after screening. The results of GO and KEGG enrichment analysis indicated that rhubarb is involved in phosphorylation, ATP binding, EGFR, HIF-1, PI3K-AKT, ESR-mediated signaling, IL-4 and IL-13 signaling pathways in cervical cancer treatment. The molecular docking results showed that rhubarb key active ingredients 3,5,3'-trihydroxy-6,7,4'-trimethoxyflavone, eupatin,5-carboxy-7-hydroxy-2-methyl-benzopyran-γ-one, rhapontigenin, chrysophanol had good docking activities with the core targets EGFR, IGF1R, AKT1, MMP9, MET, and SRC, among which AKT1 had the lowest binding energy to chrysophanol, indicating the strongest affinity between them. A variety of active ingredients in rhubarb play a therapeutic role in cervical cancer by regulating multi-targets and multiple pathways, among which, AKT1 showed higher correlation with ESR-mediated signaling, but the relevant results have to be verified by further in vitro and in vivo experiments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.