ArticlePediatric research2025
Preferences for implementing pharmacogenomics in pediatric primary care: a discrete choice experiment.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPharmacogenomics services are primarily implemented in adult specialty practices, with limited focus on pediatrics, particularly in primary care. This study aimed to assess primary care providers' preferences for implementing pharmacogenomics services in their practice.
methodsA discrete choice experiment using best-worst scaling was designed based on constructs from the Consolidated Framework for Implementation Research (CFIR) domains: Intervention Characteristics, Outer Setting, Inner Setting, Characteristics of Individuals, and Process. Questions and scenarios were developed as a survey to primary care providers at a multistate pediatric health system, to evaluate factors influencing pharmacogenomics service integration.
resultsOf 165 providers sent the survey, complete responses were received from 68 (41%). The most important constructs from the five CFIR domains were: Evidence Strength and Quality, Patient Needs and Resources, Access to Knowledge and Information, Knowledge and Beliefs, and Engaging and Champions. Least important constructs from the five domains were: Adaptability, Peer Pressure, Culture and Tension for Change, Individual Identification with Organization, and Opinion Leaders and External Change Agents.
conclusionPrimary care providers from this pediatric institution identified specific features essential for implementation of a pharmacogenomics service including engaging practitioners/champions, providing education, and establishing access to pharmacogenomic evidence and resources for providers and patients. IMPACT: Understanding pediatric providers' needs in implementing pharmacogenomics services, including education, resources, and organizational culture, is an underexplored area. The findings support informed strategies to integrate pharmacogenomics into pediatric care, enhancing its adoption into pediatric primary care. This study offers new insights into the pediatric primary care perspective on pharmacogenomics service implementation, highlighting essential priorities such as practitioner champions, targeted education, evidence access, and resource adequacy across a multistate pediatric institution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.