Evidence map›Paper›PMID 40819178›Full record

ArticleScientific reports2025

The association between dietary antioxidant index with tumor size, proliferation marker, and the odds of breast cancer in Iranian women.

Adeleh Khodabakhshi, Niloufar Rasaei, Mahmood Reza Masoudi, Mahdi Vajdi, Seyed Ali Razavi Nasab, Hossein Bavi Behbahani, Ali Akbari, Hadi Bazyar, Mostafa Dianati

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Adeleh KhodabakhshiStudent Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
Niloufar RasaeiMicronutrient Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahmood Reza MasoudiSirjan School of Medical Sciences, Sirjan, Iran.
Mahdi VajdiDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Seyed Ali Razavi NasabSirjan School of Medical Sciences, Sirjan, Iran.
Hossein Bavi BehbahaniDepartment of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ali AkbariGraduate student and Research assistant, The College of Health Sciences, The University of Memphis, Memphis, USA.
Hadi BazyarDepartment of Public Health, Sirjan School of Medical Sciences, Sirjan, Iran. hadibazyar2015@gmail.com.
Mostafa DianatiDepartment of Biomedical Sciences, Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the relationship between the dietary antioxidant index (DAI) with pathological markers (tumor size and Ki-67 marker) and the odds of breast cancer in Iranian women. In this matched case-control study, 155 women with breast cancer and 155 cancer-free women (18-70 years old) were recruited from Iran, using a convenience sampling method. Control participants were frequency-matched to cases by 5-year age-group. DAI score was calculated based on dietary data obtained from a 168-item FFQ. Linear regression with adjustment for confounding factors was used to determine the relationship between DAI and pathological markers. Logistic regression, adjusted for confounding factors, was employed to investigate the odds ratio (OR) of breast cancer according to the quantitative and qualitative (quartiles) scores of the DAI, with 95% CI. Logistic regression subgroup according to menopausal status was also performed. A non-significant inverse relationship was observed between DAI score and Ki-67 marker in the crude model and the adjusted models 2 and 3 (p ≥ 0.05). In the crude model, in the second quartile, the odds of breast cancer was significantly reduced compared to the first quartile (OR: 0.50, CI: 0.26-0.96). However, after adjusting for confounding factors in model 2, the odds of breast cancer decreased significantly in the second and third quartiles compared to the first quartile (p < 0.05). Also, by entering the DAI as a quantitative variable in model 3 of logistic regression, a significant decrease in the odds of breast cancer was observed (p = 0.03). In the postmenopausal stage, the odds of breast cancer in the second quartile decreased significantly compared to the first quartile in the crude model. Also, in model 3, after adjusting for confounding factors, the odds ratio of breast cancer in the second and third quartiles was significantly reduced compared to the first quartile (p < 0.05). This study suggests that a higher dietary antioxidant intake, as measured by the DAI, may be associated with a lower risk of breast cancer in Iranian women and this relationship is more significant in the postmenopausal stage. These findings highlight the potential benefits of dietary antioxidants and warrant further investigation into their role in breast cancer prevention strategies.

Indexed as

AntioxidantsBiomarkers, TumorBreast NeoplasmsDietAdolescentAdultAgedCase-Control StudiesCell ProliferationFemaleHumansIranKi-67 AntigenMiddle AgedOdds RatioRisk FactorsAntioxidantsBiomarkers, TumorKi-67 AntigenBreast cancerDietary antioxidant indexKi-67Pathobiological markersWomen’s health

Identifiers

PMID40819178
PMCPMC12357927

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