ArticleNPJ vaccines2025
Proteogenomic approach to immunopeptidomics of ovarian tumors identifies shared peptide vaccine candidates.
Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- An immunoinformatic strategy for developing peptide vaccines against autoimmune diseases by targeting cross-reactive bacterial antigens.Pakistan journal of medical sciences · 2026Article
- TGF-β-driven T-cell exclusion in ovarian cancer: single-cell and spatial transcriptomic views of immune low-response states.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Epithelial ovarian cancers are largely comprised of immunogenic tumor sub-types with the degree of CD8+ T cell infiltration being prognostic of clinical outcome. Tumor antigen-specific T cells are identified among these infiltrating T cell populations which has spurred a decade of development towards antigen-specific immunotherapies. Despite these efforts, the success of such immunotherapies has shown to be limited. In this study, we used state-of-the art immunopeptidomics approach and a novel proteogenomic profiling method to identify potential immunogenic human leukocyte antigen class I-presented peptides from patient-derived high-grade serous ovarian cancer. From 11 patients' tumors, we identified promising candidates for their therapeutic potential. Of these, we selected the best 13 candidates and validated their immunogenicity in both healthy donors and cancer patients.
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Registered trials
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