ArticleCell death and differentiation2026
A positive feedback loop between SERPINH1 and MMP-9/TGF-β1 promotes lung adenocarcinoma progression.
Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Lung adenocarcinoma (LUAD), the most predominant subtype of lung cancer, is a leading cause of cancer-related death worldwide. However, its underlying molecular mechanisms remain poorly understood. In this study, we identified that SERPINH1, a member of the serine protease inhibitor (serpin) superfamily, is upregulated in LUAD tissues and cells. Furthermore, high expression of SERPINH1 is associated with poor prognosis in patients. Functional experiments revealed that overexpression of SERPINH1 promotes the proliferation, invasion, and migration of LUAD cells. Further investigation showed that MMP-9 is a novel binding partner of SERPINH1. SERPINH1 enhances the protein levels of MMP-9 by inhibiting its ubiquitination, which in turn promotes the activation and secretion of extracellular TGF-β1, leading to the activation of cancer-associated fibroblasts (CAFs). Additionally, the sustained activation of TGF-β signaling further enhances the transcription of SERPINH1, establishing a positive feedback loop between SERPINH1 and TGF-β1. Taken together, our findings suggest that the SERPINH1/TGF-β1 positive feedback loop plays a crucial role in the onset and metastasis of LUAD. SERPINH1 may serve as a potential prognostic and therapeutic target in LUAD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.