Evidence map›Paper›PMID 40819088›Full record

ArticleNature communications2025

A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids.

Mingyang Li, Xiaorong Song, Haixia Tu, Jie Sun, Yuanyuan Deng, Bing Wang, Yuhan Cai, Yulian Wang, Bin Li, Yue Wang and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Mingyang LiInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0000-0001-7723-951X
Xiaorong SongInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Haixia TuDepartment of Clinical Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211100, China.
Jie SunInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Yuanyuan DengInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0009-0005-1530-1273
Bing WangState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.ORCID http://orcid.org/0000-0003-0684-2789
Yuhan CaiInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0009-0009-4750-9246
Yulian WangState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.ORCID http://orcid.org/0009-0008-1240-0921
Bin LiInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Yue WangState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.ORCID http://orcid.org/0000-0002-7670-7673
Xiangzheng ZhangState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.ORCID http://orcid.org/0009-0001-8223-151X
Dong WeiInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0009-0001-1146-5765
Xiaoyu YangState Key Laboratory of Reproductive Medicine and Offspring Health, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China.ORCID http://orcid.org/0000-0002-6411-8935
Yueshuai GuoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.ORCID http://orcid.org/0000-0002-2719-1244
Xiang LiInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Jie GuLab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Jie NiInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0009-0003-9767-5441
Yifan ZhouInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Zhongze GuInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0000-0001-8926-7710
Zhuoying XieInstitute of Microphysiological Systems, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China. zyxie@seu.edu.cn.ORCID http://orcid.org/0000-0003-3534-1924
Yan LiDepartment of Clinical Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211100, China. yanli@njmu.edu.cn.ORCID http://orcid.org/0000-0003-0420-4222
Xuejiang GuoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China. guo_xuejiang@njmu.edu.cn.ORCID http://orcid.org/0000-0002-0475-5705

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82221005, 82371606
6 · The paper itself

Abstract

Extracellular vesicles (EVs) carry complex glycoproteins critical mediators of disease progression and hold great potential for liquid biopsy applications. However, their low abundance presents significant analytical challenges. This study develop a versatile platform for EV N-glycoproteomic analysis (EVGpro), which enables tandem EV capture, EV protein digestion, and enrichment of N-glycopeptides. Functionalized magnetic nanochains with cell-penetrating peptides (octa-arginine, R

Indexed as

Body FluidsExtracellular VesiclesGlycoproteinsProteomicsBiomarkersGlycopeptidesHumansMaleSemenBiomarkersGlycopeptidesGlycoproteins

Identifiers

PMID40819088
PMCPMC12357864

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.