Evidence map›Paper›PMID 40819043›Full record

ArticleBMC oral health2025

Phosphorylated pullulan as a local drug delivery matrix for cationic antibacterial chemicals to prevent oral biofilm.

Naoko Namba-Koide, Yasuhiro Yoshida, Noriyuki Nagaoka, Takumi Okihara, Yusuke Kawata, Masahiro Ito, Takashi Ito, Kazu Takeuchi-Hatanaka, Yuki Shinoda-Ito, Kazuhiro Omori and 2 more

Abstract read
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In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Naoko Namba-KoideDepartment of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.
Yasuhiro YoshidaDepartment of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan.
Noriyuki NagaokaAdvanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.
Takumi OkiharaDivision of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama, 700- 8530, Japan.
Yusuke KawataDepartment of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.
Masahiro ItoDepartment of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.
Takashi ItoCenter for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Kazu Takeuchi-HatanakaDepartment of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.
Yuki Shinoda-ItoDepartment of Pathophysiology - Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.
Kazuhiro OmoriDepartment of Pathophysiology - Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.
Tadashi YamamotoDepartment of Pathophysiology - Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.
Shogo TakashibaDepartment of Pathophysiology - Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan. stakashi@okayama-u.ac.jp.

Funding

Japan Science and Technology Agency 2009 Young Researcher Venture Creation Promotion ProjectJapan Society for the Promotion of Science 23792174
6 · The paper itself

Abstract

backgroundPreventing oral infections, such as oral caries and periodontal disease, helps reduce the risks of various systemic diseases. In this study, the polysaccharide pullulan produced by the black yeast Aureobasidium pullulans was modified in combination with the cationic surfactant cetylpyridinium chloride (CPC) to create a local drug delivery system, and its antibacterial potential on oral bacteria was examined in vitro.

methodsPullulan was phosphorylated at the CH

resultsPP-CPC compound maintained significant bactericidal activity even at 0.01%, which is one-fifth of the conventional applicable concentration of CPC. Additionally, a residual mixture was detected by the hydroxyapatite sensor of the crystal oscillator microbalance detector, suggesting an unknown molecular interaction that enables the sustained release of CPC after attachment to hydroxyapatite.

conclusionsThe combination of PP and CPC may contribute to the low concentration and effective prevention of oral infections, such as dental caries.

Indexed as

Anti-Bacterial AgentsBiofilmsCetylpyridiniumDrug Delivery SystemsGlucansAureobasidiumBacterial AdhesionDental CariesDurapatiteHumansMicroscopy, Electron, ScanningPhosphorylationStreptococcus mutansAnti-Bacterial AgentsCetylpyridiniumDurapatiteGlucanspullulanCationic antimicrobial agentsCetylpyridinium chlorideLocal drug delivery systemOral biofilmPhosphorylated Pullulan

Identifiers

PMID40819043
PMCPMC12358065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.