Evidence map›Paper›PMID 40819027›Full record

ArticleJournal of neuroinflammation2025

Genetic polymorphisms in human CX

Dinesh Y Gawande, Sree Varshini Murali, Shriti S Thakur, Savlatjon Rahmatulloev, Emma J Nicolaisen, Lyudmila Batalkina, Astrid E Cardona, Tejbeer Kaur

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Dinesh Y GawandeDepartment of Biomedical Sciences, Creighton University, Omaha, NE, 68178, USA.
Sree Varshini MuraliDepartment of Head & Neck Surgery & Communication Sciences, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 08854, USA.
Shriti S ThakurDepartment of Head & Neck Surgery & Communication Sciences, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 08854, USA.
Savlatjon RahmatulloevDepartment of Head & Neck Surgery & Communication Sciences, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 08854, USA.
Emma J NicolaisenDepartment of Head & Neck Surgery & Communication Sciences, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 08854, USA.
Lyudmila BatalkinaDepartment of Biomedical Sciences, Creighton University, Omaha, NE, 68178, USA.
Astrid E CardonaDepartment of Molecular Microbiology and Immunology, University of Texas, San Antonio, TX, 78249, USA.
Tejbeer KaurDepartment of Biomedical Sciences, Creighton University, Omaha, NE, 68178, USA. tk755@rwjms.rutgers.edu.

Funding

Innate Immunity to Spiral Ganglion Neuron DegenerationR01DC019918 · NIDCD · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Tejbeer Kaur · 2022 to 2026
$2.5M
NIDCD NIH HHS R01 DC019918
6 · The paper itself

Abstract

Sensorineural hearing loss (SNHL) is characterized by cochlear inflammation, macrophage activation, and degeneration of hair cells, synapses, and neurons. Macrophage-mediated inflammation in the damaged cochlea is regulated via CX3CR1-CX3CL1 signaling, where the fractalkine ligand CX3CL1 serves as a chemotactic and calming signal for macrophage activation. Furthermore, disrupted CX3CR1-CX3CL1 signaling in CX3CR1-KO and CX3CL1-KO mice leads to reduced macrophage numbers, exacerbated inflammation, and loss of hair cells, ribbon synapses, and neurons in the damaged cochlea. Notably, ~ 25% of the human population carries single-nucleotide polymorphisms (SNPs) in the CX3CR1 gene, CX3CR1

Indexed as

CochleaCX3C Chemokine Receptor 1Hearing Loss, Noise-InducedHearing Loss, SensorineuralMacrophagesPolymorphism, Single NucleotideAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, KnockoutMice, TransgenicCX3C Chemokine Receptor 1CX3CR1 protein, humanCochleaCX3CR1FractalkineHair cellHearing lossInflammationMacrophageNoise traumaPolymorphismRibbon synapse

Identifiers

PMID40819027
PMCPMC12358070

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.