ReviewOdontology2026
Bioactive restorative materials in dentistry: a comprehensive review of mechanisms, clinical applications, and future directions.
Review in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of propolis-modified glass ionomer cement on antimicrobial activity and physico-mechanical properties: a systematic review.Odontology · 2026Pooled it
- Clinical performance of BioCoat™ and Fissurit FX: a randomized 18-month split-mouth study.Odontology · 2026Trial
- Clinical performance of alkasite and glass-hybrid restorations compared with resin composite in class II cavities: a randomized clinical trial.Clinical oral investigations · 2026Trial
- A two-year randomized clinical trial of bulk-fill and ion-releasing composites with universal adhesives in class V carious lesions.Clinical oral investigations · 2026Trial
- Effects of dry mouth lozenges on the surface morphology and color stability of restorative materials.Odontology · 2026Article
- Article
- Outcome and erosion of root-end filling materials following endodontic apical surgery: a minimum follow-up of 4 years.Clinical oral investigations · 2026Article
- Multidimensional Characterization of Surface Properties and Microbial Biofilm Formation in Commercial Flowable Resin-Based Dental Composites.Journal of functional biomaterials · 2026Article
- Effect of polymerization mode and LED light-curing units on the shear bond strength of an alkasite restorative material to dentin.Odontology · 2026Article
- Effects of Additive Incorporation on Fluoride Release of Orthodontic Glass Ionomer Cements and Adhesives: A Systematic Review.Materials (Basel, Switzerland) · 2026Review
- Modulating Oral Microbiota to Prevent Dental Caries: A Microbial Ecology Approach.Dentistry journal · 2026Review
- Effect of Nano-Silver Fluoride Containing 2000 ppm Silver Nanoparticles on the Microhardness and Color of Flowable Resin Composites: An In Vitro Pilot Study.Materials (Basel, Switzerland) · 2026Article
- Review
- Contemporary biomimetic and bioactive materials in paediatric dentistry: a narrative review.The Saudi dental journal · 2026Review
- Bridging the Gap Between Knowledge and Practice: Contemporary Preventive Strategies in Modern Dental Care-A Cross-Sectional Survey of Practicing Dentists.Journal of clinical medicine · 2026Article
- Hydroxyapatite-Based 3D Tooth Models for Investigating Spatially Resolved Analysis of Biofilm Formation Dynamics.ACS applied bio materials · 2026Article
- Advanced Biomaterials for Restorative Dentistry: From Biocompatibility to Bioactive and Smart Materials.Bioengineering (Basel, Switzerland) · 2026Review
- Article
- Biological Effects on S-PRG: An Integrative Review.Journal of functional biomaterials · 2026Review
- Comparative Analysis of Erosion and Erosion-Abrasion Resistance of Bioactive Glass Ionomer-Based Restorative Materials: A Surface Characterization Study.Biomimetics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioactive restorative materials represent a paradigm shift in modern dentistry, moving from passive restorations to functional materials that actively promote oral health. This review comprehensively explores the evolution, mechanisms of action, methods of assessment, and clinical applications of direct bioactive restorative materials, including glass ionomer cements (GICs), resin-based composites, and ion-releasing materials. This review critically analyzes their roles in remineralization, fluoride release, antimicrobial activity, and tissue regeneration, while also addressing their mechanical properties and limitations. A systematic literature search was conducted across major databases, including PubMed, Scopus, Web of Science, and ScienceDirect. Key findings reveal that bioactive GICs, resin-based composites, and ion-releasing materials exhibit varying degrees of bioactivity through ion release, apatite layer formation, and collagen interaction. Recent advances in calcium phosphate-based fillers, bioactive glass additives, and antimicrobial agents have significantly improved these materials' therapeutic potential. However, challenges remain regarding mechanical strength, long-term stability, and standardization of bioactivity assessment. Future research should focus on developing standardized testing protocols, optimizing mechanical performance, and conducting rigorous long-term clinical trials to fully harness the potential of bioactive restorative materials in dental practice. Also identifying the key knowledge gaps and proposing future research directions to advance the field.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.