Evidence map›Paper›PMID 40818940›Full record

ArticleBMC genomics2025

Transcriptomic analysis identifies key genes associated with nutrient deprivation responses in infectious bursal disease virus infection.

Jiaxing Wang, Qiangzhou Wang, Yuyu Ping, Xuan Huang, Ting Yang, Zongping Liu, Hao Bai, Guobin Chang, Shihao Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiaxing WangCollege of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Qiangzhou WangCollege of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Yuyu PingCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Xuan HuangCollege of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Ting YangCollege of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Zongping LiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Hao BaiCollege of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Guobin ChangCollege of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Shihao ChenCollege of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China. mrrchen@yzu.edu.cn.

Funding

National Key Research and Development Program of China 2022YFD1800300the China National Broiler Industry Technology System CARS-41the Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX24_3824
6 · The paper itself

Abstract

Infectious bursal disease virus (IBDV) causes a highly contagious and immunosuppressive disease that severely impacts the poultry industry. However, the molecular basis of IBDV-induced immunosuppression remains poorly understood. In this study, we investigate key genes implicated in this process, focusing on the interplay between metabolism and immune regulation. IBDV infection enhanced glucose and glutamine uptake in HD11 cells. Transcriptome analysis across glucose-starved, amino acid-starved, IBDV-infected, and control groups identified key differentially expressed genes (DEGs) linked to immune and metabolic pathways. Specifically, 612 DEGs were associated with glucose starvation, 998 with amino acid starvation, and 496 shared between both conditions. Enrichment analysis revealed involvement in cytokine signalling, amino acid biosynthesis, and antiviral responses. qPCR validated ENO2 and MAT1A expression changes, and a regulatory network analysis highlighted their potential roles in nutrient stress and IBDV pathogenesis. This study presents a novel strategy to identify genes involved in nutrient deprivation during IBDV infection, highlighting ENO2 and MAT1A as key contributors to immune cell dysfunction.

Indexed as

Birnaviridae InfectionsGene Expression ProfilingInfectious bursal disease virusNutrientsPoultry DiseasesTranscriptomeAmino AcidsAnimalsCell LineChickensGene Regulatory NetworksGlucoseHost-Pathogen InteractionsPhosphopyruvate HydrataseAmino AcidsGlucosePhosphopyruvate HydrataseInfectious bursal disease virusMacrophagesNutrient deprivation responseTranscriptomics

Identifiers

PMID40818940
PMCPMC12357383

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.