Evidence map›Paper›PMID 40818773›Full record

ArticleChest2026

Association Between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults With Acute Respiratory Failure.

Jose Victor Jimenez, Lingxiao Zhang, Zhenqiu Lin, Lauren E Ferrante, Jason R Falvey, Allan J Walkey, Harlan M Krumholz, Snigdha Jain

Abstract read
In one paragraph

Article in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jose Victor JimenezDepartment of Internal Medicine, Yale University, New Haven, CT.
Lingxiao ZhangDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Zhenqiu LinCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT.
Lauren E FerranteSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University, New Haven, CT.
Jason R FalveyDepartment of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD.
Allan J WalkeyDivision of Health Systems Science, Department of Medicine, UMass Chan Medical School, Worcester, MA.
Harlan M KrumholzCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT.
Snigdha JainSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University, New Haven, CT. Electronic address: snigdha.jain@yale.edu.

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Lauren Ferrante · 2002 to 2026
$37.9M
Evaluating the Unmet Needs of Older Adults to Promote Functional Recovery after a Critical Illness (LANTERN)R01AG079916 · NIA · YALE UNIVERSITY · PI Lauren Ferrante · 2023 to 2026
$3.3M
Targeting cardiovascular events to improve patient outcomes after sepsisR01HL139751 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALKEY, ALLAN J. · 2018 to 2021
$2.8M
Evaluating Routine Opioid Use during Acute Respiratory FailureR01HL151607 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIU, VINCENT, WALKEY, ALLAN J. · 2020 to 2023
$2.3M
Automated detection and prediction of atrial fibrillation during sepsisR01HL136660 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALKEY, ALLAN J. · 2017 to 2020
$2.2M
The ENRICH Study: Engaging Community and Municipal Services to Promote High Quality Aging in Place After Hip FractureK76AG074926 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI FALVEY, JASON RAYMOND · 2021 to 2025
$1.4M
Socioeconomic Disadvantage and Disability Following Critical Illness Among Older Persons: The Role of RehabilitationR03AG078942 · NIA · YALE UNIVERSITY · PI JAIN, SNIGDHA · 2022 to 2023
$335k
NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS R01 HL136660NHLBI NIH HHS R01 HL139751NHLBI NIH HHS R01 HL151607NIA NIH HHS K76 AG074926NIA NIH HHS P30 AG021342NIA NIH HHS R01 AG079916NIA NIH HHS R03 AG078942
6 · The paper itself

Abstract

backgroundOlder adults with socioeconomic disadvantage experience greater decline in function and cognition after critical illness, an adverse outcome potentially preventable through mobilization. Whether safety-net hospitals (SNHs) that serve the highest proportions of patients with socioeconomic disadvantage are less likely to deliver rehabilitation during hospitalization with stay in the ICU is unknown. RESEARCH QUESTION: Are SNHs less likely to provide rehabilitation (physical or occupational therapy or both) services to older adults hospitalized with acute respiratory failure (ARF) who receive invasive mechanical ventilation (IMV) than non-SNHs? STUDY DESIGN AND

methodsA retrospective cohort study of older adults (age ≥ 65 years) hospitalized with ARF, an ICU stay of ≥ 1 day, and receipt of IMV between 2016 and 2019 using Medicare Provider Analysis and Review files. The primary outcome was delivery of rehabilitation during hospitalization. The exposure was SNH status, defined as hospitals in the top quartile of the Disproportionate Share Hospital index. We constructed hierarchical multivariable logistic regression models with hospitals as the random effect, adjusting for patient and hospital characteristics, to evaluate the association between SNH status and rehabilitation delivery. We calculated hospital-level risk-standardized rehabilitation delivery rate and characterized variation using a median OR (MOR).

resultsWe identified 868,735 ICU hospitalizations across 1,859 US hospitals; one-half were adults between 65 and 74 years of age, 48% were female, and 77% were White. Rehabilitation was delivered in 59.1% of all hospitalizations. In the adjusted model, SNHs showed 20% lower odds of delivering rehabilitation compared with non-SNHs (adjusted OR, 0.80; 95% CI, 0.75-0.86). Hospitals varied widely in delivering rehabilitation services with a median risk-standardized rehabilitation rate of 59.4% (interquartile range, 51.7%-67.3%) and an MOR of 1.69.

interpretationSNHs showed a 20% lower odds of delivering rehabilitation to older adults hospitalized with ARF. Differences in rehabilitation delivery could be a potential mechanism for socioeconomic disparities in functional and cognitive decline after critical illness.

Indexed as

Respiratory InsufficiencySafety-net ProvidersAgedAged, 80 and overFemaleHealthcare DisparitiesHospitalizationHumansIntensive Care UnitsMaleMedicareRespiration, ArtificialRetrospective StudiesUnited Statesacute respiratory failurehealth disparitiesmechanical ventilationphysical therapysafety-net hospitals

Identifiers

PMID40818773
PMCPMC12895337

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.