Evidence map›Paper›PMID 40818459›Full record

ArticleCell reports. Medicine2025

SOX4-ZIP14-zinc metabolism mediates oncogenesis and suppresses T cell immunity in nasopharyngeal carcinoma.

Yuma Yang, Qin Liu, Jie Luo, Ziyang Qi, Shanshan Li, Lin Shen, Jishi Li, Xiaona Fang, Jiao Huang, Beilei Liu and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yuma YangDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Qin LiuDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Jie LuoDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Ziyang QiDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Shanshan LiDepartment of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Lin ShenDepartment of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Jishi LiDepartment of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Xiaona FangDepartment of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jiao HuangDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Beilei LiuDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, China.
Shan LiuDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Hongyu ZhouDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Lu BaiDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Ching Ngar WongDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Baifeng ZhangDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Danyang ZhengDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Yu ZhangDepartment of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Wei DaiDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Lanqi GongDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. Electronic address: lqgong94@hku.hk.
Xin-Yuan GuanDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, China. Electronic address: xyguan@hku.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subtle variations of micronutrients in the tumor microenvironment often coincide with tumor progression and immune disorders. Nevertheless, the underlying mechanisms of how micronutrients, such as metal ions, influence tumor-intrinsic properties and tumor-immune crosstalk remain inadequately characterized. Here, our integrative analysis of multi-center single-cell, spatial transcriptome sequencing, and bulk RNA sequencing (RNA-seq) cohorts reveals that nasopharyngeal carcinoma (NPC)-specific SRY-box transcription factor 4 (SOX4) governs microenvironmental and cellular zinc metabolism through its downstream target, SLC39A14 (ZIP14), a membrane zinc uptake transporter. Mechanistically, NPC cells enhance zinc uptake and activate Wnt/β-catenin signaling to initiate tumor growth, creating a zinc-deficient niche hostile to T cells. Zinc deficiency of tumor-infiltrating CD8

Indexed as

CarcinogenesisCation Transport ProteinsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsSOXC Transcription FactorsT-LymphocytesZincAnimalsCD8-Positive T-LymphocytesCell Line, TumorHumansMiceTumor MicroenvironmentWnt Signaling PathwayCation Transport ProteinsSOX4 protein, humanSOXC Transcription FactorsZincCD8(+) T cellsimmune resistanceLCK signalingnasopharyngeal carcinomaoncogenesisSOX4tumor microenvironmentzinc metabolismZIP14

Identifiers

PMID40818459
PMCPMC12490252

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.