SynthesisMedicina oral, patologia oral y cirugia bucal2025
Expression of regulatory and executor proteins of apoptosis in odontogenic keratocyst: a systematic review.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe odontogenic keratocyst (OKC) corresponds to the third most common odontogenic cyst of the maxillary bones, originating from the dental lamina or its remnants. Apoptosis dysregulation, due to an imbalance between anti-apoptotic and proapoptotic proteins, has been proposed as a promoter for the development and progression of OKC. This study aimed to conduct a systematic review to synthesize the current knowledge on effector proteins of the intrinsic and extrinsic pathways, and executor proteins of apoptosis in OKC and compare their expression to other odontogenic cysts and tumors. MATERIAL AND
methodsPrimary studies were searched in PubMed, Scopus, and Web of Science databases, following the recommendations of PRISMA. Inclusion criteria were articles in English reporting the expression of at least two apoptosis-related proteins in OKC, studies using human tissues, descriptive retrospective case series, or in vitro assays.
resultsSeven articles met the inclusion criteria and were considered for data extraction and analysis. Of the selected articles, six studied proteins related to the regulation of the intrinsic pathway of apoptosis, all reporting the immunohistochemical expression of Bcl-2 and BAX. Only one study reported the immunohistochemical expression of proteins related to the regulation of the extrinsic pathway, specifically Fas and FasL. Regarding apoptosis execution proteins, only one article characterized the immunohistochemical expression of caspases, specifically caspase-3.
conclusionsOKC expresses proteins related to apoptosis regulation similar to other aggressive odontogenic lesions, such as ameloblastoma. This suggests that apoptosis dysregulation may be essential in its development and progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.