ArticleMedicina oral, patologia oral y cirugia bucal2025
Cluster and correspondence analyses for oral ulcer activity related factors in Behçet's syndrome.
Article in Medicina oral, patologia oral y cirugia bucal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBehçet's Syndrome (BS) is a multisystemic vasculitis characterized by a heterogeneous clinical profile, including mucocutaneous, musculoskeletal, neurological, ocular, vascular and gastrointestinal manifestations. BS patients often experience a continuous, low-level disease activity state due to persistent oral ulcers. This study aimed to define relations among oral ulcer activity (OUA), gender and treatments through K-Means Cluster and Correspondence Analyses (CA) in patients with BS. MATERIAL AND
methodsIn this cross-sectional study, 526 BS patients from two tertiary centres in Turkey and the United Kingdom were included. The K-Means Cluster Analysis was performed to identify homogeneous clinical profiles for OUA by combining the disease severity score reflecting organ involvement and the number of oral ulcers. Then, CA was performed to visualize associations between gender and medications (non-immunosuppressive: non-IS vs. IS) in clusters.
resultsK-Means Analysis identified three clusters regarding mucocutaneous and major organ involvement and cluster regarding with major organ involvement. Clusters were named according to OUA and the disease severity. The number of oral ulcers was found to be similar in the "Low OUA" cluster (n=202, 65.03%; 2.18±1.13) and the "Low OUA with Major Organ Involvement" cluster (n=63, 19.25%; 2.19±1.37) (p=0.368). These were lower than those in the "Moderate OUA" Cluster (n=30, 9.8%; 7.60±1.88) and the "High OUA" cluster (n=11, 3.59%; 14.91±2.34) (p<0.001). CA visualized that non-ISs in "Low OUA" cluster, ISs in "Low OUA with Major Organ" cluster for both genders as well as male patients treated with non-ISs or ISs in "Moderate OUA" cluster were predominant groups.
conclusionsThe presence of two oral ulcers might be accepted as the cut-off value for low OUA. Moreover, intensive treatment protocols must be provided for elevated oral ulcer activity in male patients who were treated with non-IS medications in BS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.