SynthesisMedicina oral, patologia oral y cirugia bucal2025
Exploring potential salivary biomarkers for dental caries: a systematic review.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Obesity and Dental Caries: A State-of-the-Art Review of Shared Risk Factors, Biological Mechanisms and Current Evidence.Medical sciences (Basel, Switzerland) · 2026Review
- A chlorine releasing solution as an alternative for dental biofilm control.Scientific reports · 2026Article
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Authors and funding
2 authors.
Funding
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Abstract
backgroundDental caries remains one of the most widespread non-communicable diseases. Saliva is crucial for maintaining oral health as it shields teeth from demineralization and promotes the remineralization of enamel. Although ongoing studies are investigating the relationship between various salivary proteins and dental caries, consensus in existing literature has not yet been established. This study aims to provide additional insights into the current research of salivary protein biomarkers association with dental caries. MATERIAL AND
methodsThis systematic review analyzed literature published between January 2013 to December 2023, retrieved from PubMed, Scopus, and Web of Science.
resultsThe review included 21 observational studies (2 cohort, 2 case-control, and 17 cross-sectional) involving over 2,000 participants, examining 18 different proteins. There was considerable variability in the types of salivary markers studied. Among the participants, 54% were diagnosed as caries-active (CA), while 45.9% were caries-free (CF), with ages ranging from 6 to 89 years. The Newcastle-Ottawa Scale indicated that the risk of bias was low in 10 studies, intermediate in 10, and high in 1.
conclusionsEighteen studies found significant differences in protein expression between CA and CF subjects, underscoring the potential of using salivary biomarkers for non-invasive diagnose assessment. However, larger and greater designed studies are needed to establish their clinical value. Besides, divergent results from proteomic studies on biomarkers may be due to variations in genetics, diet, oral hygiene, age and other factors of the subjects, which could affect the reliability of saliva biomarkers in caries screening and detection. The significant heterogeneity among studies made conducting a proper meta-analysis infeasible.
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