Evidence map›Paper›PMID 40818076›Full record

ArticleAutophagy2025

Neutralization of the autophagy-repressive tissue hormone DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) for the treatment of hepatocellular carcinoma.

Sijing Li, Flavia Lambertucci, Isabelle Martins, Jonathan Pol, Maria Chiara Maiuri, Guido Kroemer

Abstract read
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sijing LiTeam "Metabolism, Cancer & Immunity", Équipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, UMRS1138, Inserm, Université Paris Cité, Sorbonne Université, Paris, France.ORCID 0009-0003-1535-6050
Flavia LambertucciTeam "Metabolism, Cancer & Immunity", Équipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, UMRS1138, Inserm, Université Paris Cité, Sorbonne Université, Paris, France.ORCID 0000-0002-2719-6635
Isabelle MartinsTeam "Metabolism, Cancer & Immunity", Équipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, UMRS1138, Inserm, Université Paris Cité, Sorbonne Université, Paris, France.ORCID 0000-0003-0885-613X
Jonathan PolTeam "Metabolism, Cancer & Immunity", Équipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, UMRS1138, Inserm, Université Paris Cité, Sorbonne Université, Paris, France.ORCID 0000-0002-8355-7562
Maria Chiara MaiuriTeam "Metabolism, Cancer & Immunity", Équipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, UMRS1138, Inserm, Université Paris Cité, Sorbonne Université, Paris, France.ORCID 0000-0001-9760-7674
Guido KroemerTeam "Metabolism, Cancer & Immunity", Équipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, UMRS1138, Inserm, Université Paris Cité, Sorbonne Université, Paris, France.ORCID 0000-0002-9334-4405

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein), which is a major macroautophagy/autophagy-repressive protein, is emerging as a key player in hepatocellular carcinoma (HCC) pathogenesis through multifaceted roles that encompass both cell-intrinsic and -extrinsic mechanisms. Beyond promoting cancer cell proliferation, DBI/ACBP contributes to a pro-tumorigenic microenvironment by sustaining inflammation and impairing immunosurveillance. Experimental models of HCC, whether induced by oncogenes, hepatotoxins, or diet, consistently reveal that hepatocyte-specific knockout of

Indexed as

AutophagyCarcinoma, HepatocellularDiazepam Binding InhibitorLiver NeoplasmsAnimalsCell Line, TumorHumansMiceDiazepam Binding InhibitorAgingimmunityimmunosurveillanceinflammationsenescence

Identifiers

PMID40818076
PMCPMC12459354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.