SynthesisProbiotics and antimicrobial proteins2026
Does Probiotic Therapy Improve Periodontal Treatment Outcomes in Smoking Patients? A Systematic Review of Randomized Clinical Trials.
Synthesis in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A scientometric analysis of research related to the 'oral-placental axis' hypothesis: current status, hotspots, and future directions.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aimed to assess the efficacy of probiotics on clinical parameters in smoking patients with periodontal diseases. An electronic search was carried out, without date or language restrictions, in the PubMed, Web of Science, Embase, and Scopus databases for identification of clinical trials whose population consisted of smokers with gingivitis or periodontitis, undergoing probiotic therapy associated to non-surgical periodontal therapy, and that carried out evaluation of periodontal clinical parameters. The risk of bias was assessed using the Joanna Briggs Institute Critical Assessment Checklist. Among the 162 studies identified, four were eligible for qualitative synthesis. Eight probiotic species were identified, predominantly Lactobacilli, with L. reuteri being the most prevalent. These probiotics were administered in tablet or lozenge form. Probiotics, in combination with non-surgical periodontal therapy, demonstrated reductions in gingival index, probing pocket depth, and bleeding on probing. Furthermore, probiotics exhibited efficacy comparable to antibiotics in grade C periodontitis treatment. Risk of bias was deemed low across all studies. Within the limitations of this review, it can be concluded that probiotic therapy appears to confer benefits to non-surgical periodontal therapy in smoking patients.
Indexed as
Identifiers
40818019What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.