Anterior scleritis with IgG4 lymphoplasmacytic infiltration: a case report.

Poojitha Balakrishnan, Matthew G Vicinanzo, John P Luckett, Tom Winokur, Ryan S Weldon, Russell W Read

Abstract read

In one paragraph

Article in Journal of ophthalmic inflammation and infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Poojitha BalakrishnanDepartment of Ophthalmology and Visual Sciences, University of Alabama School of Medicine, 1720 University Boulevard, Suite 302, Birmingham, AL, 35233, USA. pbalakr2@jh.edu.

Matthew G VicinanzoDepartment of Ophthalmology and Visual Sciences, University of Alabama School of Medicine, 1720 University Boulevard, Suite 302, Birmingham, AL, 35233, USA.

John P LuckettDepartment of Ophthalmology and Visual Sciences, University of Alabama School of Medicine, 1720 University Boulevard, Suite 302, Birmingham, AL, 35233, USA.

Tom WinokurDepartment of Pathology and Anatomic Pathology, University of Alabama School of Medicine, Birmingham, AL, USA.

Ryan S WeldonRheumatology Associates, Birmingham, AL, USA.

Russell W ReadDepartment of Ophthalmology and Visual Sciences, University of Alabama School of Medicine, 1720 University Boulevard, Suite 302, Birmingham, AL, 35233, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report a case of chronic unilateral nodular anterior scleritis as a rare, isolated presentation of IgG4-related ophthalmic disease. CASE: A fifty-two-year-old patient was evaluated for painful, nodular scleral injection of the right eye, diagnosed as nodular anterior scleritis. There was only a partial response to topical corticosteroid and systemic immunomodulatory therapy. This, in combination with a sharp delineation between normal and abnormal sclera lead to the decision to perform a diagnostic biopsy of the lesion. Histopathology showed an IgG4 lymphoplasmacytic infiltration of the scleral tissue.

conclusionsThere are few documented reports of scleritis as the presenting manifestation of IgG4-related disease. IgG4-related disease is an increasingly recognized etiology to be considered in evaluating and managing scleritis.

Indexed as

Anterior scleritisIgG4-related diseaseLymphoplasmacytic inflammatory disease

Identifiers

PMID40818017

DOI10.1186/s12348-025-00516-3

PMCPMC12357819

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