Toxicity and antiproliferative activity assessment of a novel compound Zr I isolated from Zingiber roseum Rosc.

Swarnalatha P, Deepika Divya K, Anjali Jha, Anitha M, S P D Ponamgi, Seema Kumari, Sujatha Peela

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Swarnalatha PMulti-Disciplinary Research Unit, Andhra Medical College, KGH, Visakhapatnam, AP, India.

Deepika Divya KResearch and Development Division, Trivitron Healthcare, AMTZ, Visakhapatnam, AP, India.

Anjali JhaGITAM University, Rushikonda, Visakhapatnam, AP, India.

Anitha MGITAM University, Rushikonda, Visakhapatnam, AP, India.

S P D PonamgiDepartment of Biotechnology, Andhra University, Visakhapatnam, AP, India.

Seema KumariDepartment of Biotechnology, Dr. B.R. Ambedkar University, Srikakulam, AP, India.

Sujatha PeelaDepartment of Biotechnology, Dr. B.R. Ambedkar University, Srikakulam, AP, India. drpsujatha@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secondary metabolites from the Zingiberaceae family are enormously active compounds used especially in traditional medicine practices and can be effective drugs in cancer treatment. 8-Isopropyl-5,11-dimethyl-dodecane-4,5-diol (Zr I) was isolated from chloroform extract of Zingiber roseum rhizome and analyzed for anticancer activity against MCF-7 breast cancer cell line. The structure was elucidated based on advanced IR, GC MS, and 2D NMR spectral data. The anti-proliferative activity of Zr I was assessed in the MCF-7 cell line. Brine shrimp lethality assay, Sister chromatid exchange assay, and LAZAR toxicity prediction methods estimated the compound's toxicity. In this study, Zr I found to induce cell death in MCF-7 cells with an IC₅₀ value of 16.81 µM, which is relatively lower than the IC

Indexed as

Antineoplastic Agents, PhytogenicCell ProliferationFatty AlcoholsPlant ExtractsZingiberaceaeAnimalsArtemiaBreast NeoplasmsFemaleHumansInhibitory Concentration 50MCF-7 CellsRhizomeAntineoplastic Agents, PhytogenicFatty AlcoholsPlant ExtractsAdvanced spectral data analysis-2D NMRAnti-proliferativeBioactive compound Zr ICytotoxicity analysisGC MSIRZingiber roseum

Identifiers

PMID40817918

DOI10.1007/s00210-025-04466-4

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