Evidence map›Paper›PMID 40817754›Full record

ArticleVirulence2025

Intratumorally specific microbial-derived lipopolysaccharide contributes to non-small cell lung cancer progression.

Guomeng Sha, Zhengwen Wu, Biao Wang, Yi Ding, Zhaohua Xiao, Wenhao Zhang, Jie Zhou, Yongjia Zhou, Guanhong Ji, Zhongxian Tian and 2 more

Abstract read
In one paragraph

Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guomeng ShaDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Zhengwen WuDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Biao WangDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Yi DingDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Zhaohua XiaoDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Wenhao ZhangDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Jie ZhouDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Yongjia ZhouDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Guanhong JiDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Zhongxian TianDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Weiquan ZhangDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.
Xiaogang ZhaoDepartment of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, People's Republic of China.ORCID 0000-0002-5521-1628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an emerging component of the tumor microenvironment (TME), the intratumoural microbiota imperceptibly influences the progression of various human malignancies. However, the critical intratumoural microbiota and its role in non-small cell lung cancer (NSCLC) progression have not been fully elucidated. Here, we used high-throughput sequencing and clinical samples analysis to identify the relationship between intratumoural bacteria and NSCLC progression. The results showed that significant abnormalities in the intratumoural microbiota of NSCLC. Specifically, the relative abundance of gram-negative bacteria in tumor was significantly increased, and network analysis revealed that

Indexed as

Carcinoma, Non-Small-Cell LungLipopolysaccharidesLung NeoplasmsMicrobiotaAnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleHumansInterleukin-6MaleMiceMice, Inbred BALB CNF-kappa BToll-Like Receptor 4Interleukin-6LipopolysaccharidesNF-kappa BTLR4 protein, humanToll-Like Receptor 4TOR Serine-Threonine KinasesEscherichia-shigellaIntratumoural microbiota dysbiosislipopolysaccharidenon-small cell lung cancerUnclassified_f_enterobacteriaceae

Identifiers

PMID40817754
PMCPMC12363524

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.