Evidence map›Paper›PMID 40817749›Full record

ArticleJournal of peptide science : an official publication of the European Peptide Society2025

Silica-Assisted Solid-Phase Peptide Synthesis (SiPPS).

Nonsikelelo Nkwanyana, Ashish Kumar, Amit Chakraborty, Steeves Potvin, Georges Thibaut-Koumba, Brunello Nardone, Francois Beland, Anamika Sharma, Beatriz G de la Torre, Fernando Albericio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of peptide science : an official publication of the European Peptide Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Silica-Assisted Solid-Phase Peptide Synthesis (SiPPS).Journal of peptide science : an official publication of the European Peptide Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nonsikelelo NkwanyanaPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
Ashish KumarPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
Amit ChakrabortyPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
Steeves PotvinSiliCycle Inc., Quebec City, Quebec, Canada.
Georges Thibaut-KoumbaSiliCycle Inc., Quebec City, Quebec, Canada.
Brunello NardoneSiliCycle Inc., Quebec City, Quebec, Canada.
Francois BelandSiliCycle Inc., Quebec City, Quebec, Canada.
Anamika SharmaPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
Beatriz G de la TorreSchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Fernando AlbericioPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.ORCID https://orcid.org/0000-0002-8946-0462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-swelling silica-based resin was used for peptide synthesis. The strategy used is similar to that of solid-phase peptide synthesis (SPPS), referred to as silica-assisted solid-phase peptide synthesis (SiPPS). A 2-h coupling seemed to favor the coupling compared to that of 1-h standard coupling. The use of this non-swelling resin allows a 50% reduction in the consumption of solvents. The strategy was well demonstrated for the synthesis of H-YSSFL-NH

Indexed as

PeptidesSilicon DioxideSolid-Phase Synthesis TechniquesAngiotensin IIOxytocinAngiotensin IIOxytocinPeptidesSilicon Dioxideafamelanotideangiotensin IIlinear oxytocinnon‐swellingpeptide synthesissilica resin

Identifiers

PMID40817749
PMCPMC12357219

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.