Evidence map›Paper›PMID 40817746›Full record

ArticleChemical biology & drug design2025

Morpholine-Facilitated Enrichment-Triggered Delivery of Carbon Monoxide to Lysosome: A Feasibility Study.

Ravi Tripathi, Dongning Liu, Xiaoxiao Yang, Ce Yang, Wen Lu, Qiyue Mao, Binghe Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical biology & drug design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ravi TripathiDepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-9912-3374
Dongning LiuDepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0008-0505-6851
Xiaoxiao YangDepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, USA.
Ce YangDepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, USA.
Wen LuDepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, USA.
Qiyue MaoDepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-2834-5890
Binghe WangDepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, USA.

Funding

Examining Carbon Monoxide to Treat Inflammatory Conditions using Experimental Colitis ModelsR01DK119202 · NIDDK · GEORGIA STATE UNIVERSITY · PI OTTERBEIN, LEO E, TAN, CHALET · 2019 to 2023
$3.6M
Early-Stage Preclinical Validation of Carbon Monoxide Prodrugs for Acute Kidney InjuryR01DK128823 · NIDDK · GEORGIA STATE UNIVERSITY · PI LEO E OTTERBEIN, Binghe Wang · 2022 to 2026
$3.5M
A Xevo G2-XS Mass Spectrometer Equipped with an Acquity UPLC as a Workhorse Instrument to Replace a 15-year old Waters Q-TOF MicroS10OD026764 · OD · GEORGIA STATE UNIVERSITY · PI WANG, SIMING · 2020 to 2020
$428k
NIDDK NIH HHS R01 DK119202NIDDK NIH HHS R01 DK128823NIH HHS R01DK119202NIH HHS R01DK128823NIH HHS S10 OD026764NIH HHS S10OD026764
6 · The paper itself

Abstract

Targeted delivery of carbon monoxide (CO) prodrugs holds important therapeutic potential for various applications. Along this line, we developed an enrichment-triggered release (ETR) approach for activating 2-component (a diene and a dienophile) CO prodrugs upon enrichment in the mitochondrion, giving a "one stone, two birds" approach. Herein, we aim to broaden the scope of application to targeted delivery to the lysosome. We tethered a CO prodrug pair, a diene and a dienophile, with morpholine, a lysosomal targeting moiety. Several analogs were synthesized to tune the second-order rate constants (k

Indexed as

Carbon MonoxideLysosomesMorpholinesProdrugsDrug Delivery SystemsFeasibility StudiesHeLa CellsHumansCarbon MonoxidemorpholineMorpholinesProdrugsclick chemistrygasotransmitterslysosome‐targeted deliveryorganic CO prodrug

Identifiers

PMID40817746
PMCPMC12534755

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.