Evidence map›Paper›PMID 40817680›Full record

ArticleAdvanced healthcare materials2025

Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells.

Mitchell Mostina, Jane Sun, Seen Ling Sim, Imaan A Ahmed, Fernando Souza-Fonesca-Guimaraes, Ernst J Wolvetang, Jason Brown, Snehlata Kumari, Kiarash Khosrotehrani, Abbas Shafiee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
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  5. [Research advances on the application of skin appendage organoids in wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mitchell MostinaExperimental Dermatology Group, Dermatology Research Centre, The University of Queensland Frazer Institute, The University of Queensland, Brisbane, QLD, 4102, Australia.
Jane SunExperimental Dermatology Group, Dermatology Research Centre, The University of Queensland Frazer Institute, The University of Queensland, Brisbane, QLD, 4102, Australia.
Seen Ling SimExperimental Dermatology Group, Dermatology Research Centre, The University of Queensland Frazer Institute, The University of Queensland, Brisbane, QLD, 4102, Australia.
Imaan A AhmedExperimental Dermatology Group, Dermatology Research Centre, The University of Queensland Frazer Institute, The University of Queensland, Brisbane, QLD, 4102, Australia.
Fernando Souza-Fonesca-GuimaraesThe University of Queensland Frazer Institute, The University of Queensland, Woolloongabba, Brisbane, QLD, 4102, Australia.
Ernst J WolvetangAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
Jason BrownRoyal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Queensland Health, Brisbane, QLD, 4029, Australia.
Snehlata KumariExperimental Dermatology Group, Dermatology Research Centre, The University of Queensland Frazer Institute, The University of Queensland, Brisbane, QLD, 4102, Australia.
Kiarash KhosrotehraniExperimental Dermatology Group, Dermatology Research Centre, The University of Queensland Frazer Institute, The University of Queensland, Brisbane, QLD, 4102, Australia.
Abbas ShafieeExperimental Dermatology Group, Dermatology Research Centre, The University of Queensland Frazer Institute, The University of Queensland, Brisbane, QLD, 4102, Australia.ORCID 0000-0002-8885-9025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human skin is a highly vascularized organ, where blood vessels perform essential roles in maintaining skin homeostasis and participate in thermal regulation. Currently, there is an unmet challenge to generate vascularized, functional skin models. In this study, human fetal placental endothelial colony forming cells (ECFC) are incorporated into human induced pluripotent stem cell (hiPSC)-derived skin organoids (SKO), forming capillary-like structures and generating endothelialized SKOs. However, this approach is limited by the inability of ECFCs to establish a complete vascular network, and impeding full epidermal stratification and hair follicle morphogenesis. In independent experiments, hiPSC-derived vascular organoids (VO), are incorporated into the SKO, forming complex vascular structures and generating fully vascularized skin organoids (VSKO) with resident immune cell populations. Immunofluorescence microscopy and flow cytometric analyses reveal the transfer and integration of endothelial, mural, hematopoietic, and mesenchymal cells from VOs into the skin components of VSKOs. This study pioneers the establishment of VSKOs as a transformative platform for studying human skin biology, and immune-skin interactions with applications in investigating inflammatory and other immune-mediated skin disorders.

Indexed as

Induced Pluripotent Stem CellsOrganoidsSkinCell DifferentiationEndothelial CellsHumansbiofabricationdisease modelinghair follicleregenerative medicinewound healing

Identifiers

PMID40817680
PMCPMC12683213

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.