Trial reportAnnals of clinical and translational neurology2025
Bilateral versus Unilateral Training With Rhythmic Auditory Cueing in Stroke Rehabilitation: Effects on Upper Limb Function and Interhemispheric Inhibition.
Trial report in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A bilateral upper limb interactive game-based virtual reality rehabilitation system for stroke patients: a usability and clinical study.Journal of neuroengineering and rehabilitation · 2026Trial
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundStroke is a leading cause of long-term disability in adults, with upper limb hemiparesis being a common impairment. Traditional training is mostly aimed at paralyzed limbs, but the effect of bilateral training is still unclear.
objectiveThis study explores the influence and mechanism of unilateral and bilateral rhythmic task training on the rehabilitation of stroke patients. STUDY
designThis was a double-blind randomized controlled trial.
methodsThirty-six patients were randomly assigned to the bilateral group or to the unilateral group. The bilateral group engaged in repetitive training involving both arms and distal hand movements, while the unilateral group focused on the affected arm. Evaluations were performed before treatment and immediately after treatment. The outcome measures included Fugl-Meyer Upper Extremity (FMA-UE), the average electromyographic values of a total of 16 muscle groups on both the unaffected and affected sides (with 8 muscle groups on each side) during maximum voluntary isometric contraction, as well as the active range of motion (ROM). Changes in interhemispheric inhibition (IHI) were assessed using transcranial magnetic stimulation.
resultsPost-treatment assessments indicated that the FMA-UE scores significantly increased in both groups, with the bilateral group exhibiting more pronounced improvements (p = 0.031; ηp
conclusionBilateral training is more effective than unilateral training in enhancing upper limb function and may contribute to balancing IHI in stroke recovery patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.