Evidence map›Paper›PMID 40817634›Full record

ArticleAdvanced healthcare materials2025

Norbornene Homopolymerization Limits Cell Spreading in Thiol-Ene Photoclick Hydrogels.

James L Gentry, Steven R Caliari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James L GentryDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22903, USA.
Steven R CaliariDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22903, USA.ORCID 0000-0002-7737-7987

Funding

Aligned and electrically conductive collagen scaffolds for guiding innervated muscle-tendon junction repair of volumetric muscle loss injuriesR01AR078866 · NIAMS · UNIVERSITY OF VIRGINIA · PI CALIARI, STEVEN · 2021 to 2025
$2.0M
National Science Foundation CAREER2046592NIAMS NIH HHS R01 AR078866NIAMS NIH HHS R01AR078866
6 · The paper itself

Abstract

Thiol-ene click chemistry is a powerful tool for engineering tissue-mimicking hydrogels permissive to 3D cell spreading. Thiol-norbornene chemistry allows precise control over crosslinking while seemingly avoiding alkene homopolymerization that can restrict 3D cell spreading. However, limited stress relaxation of a guest-host crosslinked norbornene-modified hyaluronic acid (NorHA) hydrogel employing a thiol-norbornene photoclick reaction prompts investigation into unintended norbornene homopolymerization. Norbornene conversion exceeds 1:1 thiol-ene expectations across various formulations, implicating homopolymerization. Reducing the number of norbornenes per NorHA chain (f) mitigates network formation via norbornene homopolymerization. Guest-host hydrogels fabricated with Nor

Indexed as

HydrogelsMesenchymal Stem CellsNorbornanesSulfhydryl CompoundsClick ChemistryHumansHyaluronic AcidPolymerizationTissue Engineering2-norborneneHyaluronic AcidHydrogelsNorbornanesSulfhydryl Compoundscell spreadinghydrogelsnorbornene homopolymerizationstress relaxation

Identifiers

PMID40817634
PMCPMC12716181

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.