ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2025
How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration: Shared Mechanisms Between Growth Cones of Migrating Neurons and Axons.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Neuronal migration into injured tissue: mechanisms and therapeutic strategies for brain regeneration.Regenerative therapy · 2026Review
- How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration: Shared Mechanisms Between Growth Cones of Migrating Neurons and Axons.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Migrating neurons form a growth cone at the tip of their leading process. This specialized structure shares striking anatomical and functional similarities with axonal growth cones. We hypothesize that both cones respond to common extracellular cues and direct neuronal migration and axon extension, respectively, through analogous mechanisms. Guidance cues provide growth cones with attractive or repulsive signals to direct them towards their targets. By binding to specific receptors on growth cones, these cues trigger intracellular signaling pathways that reorganize the cytoskeleton and propel neurons or axons in precise directions. Notably, many of the receptors that mediate axon guidance are also present in the growth cones of migrating neurons, reinforcing the idea of a conserved molecular machinery. Elucidating the molecular mechanisms underlying growth cone dynamics in migrating neurons promises to deepen our understanding of neuronal development, and to pave the way for new regenerative therapies aimed at promoting neuronal migration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.