Evidence map›Paper›PMID 40817598›Full record

ArticleClinical and translational medicine2025

Intestinal Fut2 deficiency exacerbated alcohol-related liver disease by disrupting nicotinamide metabolism.

Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liuying ChenDepartment of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhongwei YinDivision of Cardiology and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Luorui ShangDepartment of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hang YuanDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wenkang GaoDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shuhan WangDepartment of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shuyan WangDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaohua HouDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shenglan YangDepartment of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huikuan ChuDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0001-5349-8429

Funding

National Key R&D Program of China 2022YFA1305600National Natural Science Foundation of China 81974062National Natural Science Foundation of China 82000561National Natural Science Foundation of China 82100375National Natural Science Foundation of China 82274314National Natural Science Foundation of China 82400652National Natural Science Foundation of China 82470584Scientific Research Foundation of Wuhan Union Hospital 2023XHYN019
6 · The paper itself

Abstract

backgroundFucosyltransferase 2 (FUT2)-dependent fucosylation of intestinal epithelial cells is vital for preserving gut barrier integrity and microbial balance. Nevertheless, its precise involvement in alcohol-associated liver disease has yet to be fully elucidated.

methodsWe generated mice with intestinal epithelial cell-specific Fut2 knockout (Fut2

resultsThe loss of intestinal epithelial Fut2 exacerbates alcohol-related hepatic oxidative stress damage, and this effect is dependent on gut bacteria. A marked decrease in the abundance of bacteria carrying nicotinamidase (PncA) in the intestines of Fut2

conclusionThese findings reveal a gut microbiota-Fut2-pncA axis that modulates alcoholic liver injury in mice, which may offer insights into microbial contributions to alcoholic liver disease in people. KEY POINTS: Loss of intestinal epithelial fucosylation exacerbates alcohol-related liver injuries. Intestinal epithelial deletion of Fut2 disrupts nicotinamide (NAM) metabolism due to the decline in bacterial nicotinamidase (PncA). Supplemented with pncA overexpressed E.coli to restore gut PncA levels can improve liver damage in alcohol-induced intestinal epithelial Fut2 deletion mice.

Indexed as

FucosyltransferasesLiver Diseases, AlcoholicNiacinamideAnimalsDisease Models, AnimalGalactoside 2-alpha-L-fucosyltransferaseGastrointestinal MicrobiomeIntestinal MucosaMaleMiceMice, Inbred C57BLMice, KnockoutFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseNiacinamidealcohol‐related liver diseasefucosyltransferase 2NADnicotinamidase

Identifiers

PMID40817598
PMCPMC12356993

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.