Evidence map›Paper›PMID 40817579›Full record

ArticleAdvanced healthcare materials2025

Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model.

Martin Stark, Fereshteh Bayat, Sara Rahmani, Mathura Thirugnanasampanthar, Taylor Kramer, Elise Schwarz, David Wilson, Jeffrey I Weitz, Zeinab Hosseinidoust, Tohid F Didar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin StarkSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.ORCID 0000-0003-0013-0975
Fereshteh BayatSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Sara RahmaniSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Mathura ThirugnanasampantharDepartment of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Taylor KramerDepartment of Mechanical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Elise SchwarzDepartment of Mechanical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
David WilsonHalifax Infirmary, 1796 Summer St., Halifax, NS, B3H 3A6, Canada.
Jeffrey I WeitzDepartment of Medicine, Thrombosis and Atherosclerosis Research Institute, and Hamilton Health Sciences, McMaster University, Hamilton, ON, L8S 4K1, Canada.
Zeinab HosseinidoustSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Tohid F DidarSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.ORCID 0000-0002-8757-8002

Funding

Canada Research Chairs ProgramDiscovery Grants Program and the Ontario Early Researcher Awards ProgramElectron Microscopy Facility in the Health Sciences Centre at McMaster UniversityNatural Sciences and Engineering Research Council of Canada
6 · The paper itself

Abstract

Implant-associated infections remain a significant complication in medicine. often leading to chronic infection, tissue damage, or implant failure. To address this, this work develops a modular, triple-action titanium implant that integrates bacterial repellency, bactericidal activity, and enhanced tissue integration. The implant comprises medical-grade titanium with a co-deposited layer of bacteriophages and collagen stably embedded within a repellent lubricant layer. The collagen layer promotes cell deposition and spreading in vitro. When tested against Pseudomonas aeruginosa, the coating reduces bacterial load by 3.2 logs on the surface and 1.9 logs in the medium, outperforming conventional liquid-infused surfaces. A modified version targeting Staphylococcus aureus achieves 4.1-log and 5.2-log reductions, respectively, after a 6-h incubation. When challenging the coating in a sepsis survival model of Pseudomonas aeruginosa infection, mice with the phage-activated implants exhibit a 100% survival rate and fully recover from the infection. In comparison, those with pathogen-repellent and untreated titanium implants show survival rates of only 30% and 10%, respectively. Furthermore, phage, but no bacteria, are detected in the bloodstream of mice implanted with phage-activated titanium, suggesting that locally implanted phage-biomaterials can distribute systemically to control blood infections. Therefore, the engineered phage-activated, triple-action biomaterials may prevent implant-associated infections locally and systemically.

Indexed as

Prostheses and ImplantsSepsisAnimalsAnti-Bacterial AgentsBacteriophagesCoated Materials, BiocompatibleCollagenDisease Models, AnimalMicePseudomonas aeruginosaPseudomonas InfectionsStaphylococcus aureusTitaniumAnti-Bacterial AgentsCoated Materials, BiocompatibleCollagenTitaniumantibacterial‐coatingbacteriophagesmedical implantmouse sepsis model

Identifiers

PMID40817579
PMCPMC12716215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.