Evidence map›Paper›PMID 40817451›Full record

ReviewVirulence2025

Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways.

Penghao Lv, Zhichao Wang, Haowei Chen, Yanru Chen, Hanlin Liao, Kaiyue Wei, Shuying Lv, Min Cui

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Penghao LvState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
Zhichao WangState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
Haowei ChenState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
Yanru ChenState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
Hanlin LiaoState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
Kaiyue WeiState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
Shuying LvDepartment of English Teaching and Research Section, Dongying Vocational College, Dongying, China.
Min CuiState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.ORCID 0000-0001-9691-033X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever virus (ASFV), a highly lethal pathogen, poses a catastrophic threat to global pork production. While some commercial vaccines exist, their availability remains regional limitations. This review investigates the mechanistic interplay between ASFV and antigen-presenting cells (APCs), with a particular focus on viral evasion strategies that disrupt antigen presentation pathways. Although current understanding of ASFV immunology has largely focused on monocyte/macrophage infection, we provide a systematic analysis of ASFV-mediated immunosuppression across various APCs, including dendritic cells (DCs), B lymphocytes, and γδ T cells, and compare these mechanisms with those employed by other viral pathogens. Key objectives include: (1) synthesizing ASFV-induced dysregulation of antigen presentation, (2) identifying critical gaps in APC-virus interactions, and (3) guiding vaccine development priorities. By highlighting understudied DC-ASFV interplay and potential molecular targets, this work provides a strategic framework for next-generation vaccine design based on host-pathogen conflict at the antigen presentation interface.

Indexed as

African Swine FeverAfrican Swine Fever VirusAntigen PresentationHost-Pathogen InteractionsImmune EvasionAnimalsAntigen-Presenting CellsDendritic CellsSwineadaptive immunityAfrican swine feverAfrican swine fever virusantigen presentationvaccines

Identifiers

PMID40817451
PMCPMC12360204

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.