ArticleScientific reports2025
The aggregate index of systemic inflammation is positively correlated with the risk of all-cause mortality in sepsis-associated acute kidney injury.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Advanced lung cancer inflammation index is associated with mortality in critically ill patients with acute kidney injury.Clinics (Sao Paulo, Brazil) · 2026Article
- Prognostic value of the aggregate index of systemic inflammation in palliative care patients.Scientific reports · 2026Article
- Metabolic Dysregulation, Inflammation, and Median Nerve Dysfunction in Patients with Type 2 Diabetes Mellitus with Carpal Tunnel Syndrome.International journal of molecular sciences · 2026Article
- CBC-derived inflammatory indices predict adverse outcomes in geriatric emergency patients with acute infectious diarrhea: a MIMIC-IV analysis.Scientific reports · 2026Article
- Association between red blood cell distribution width to albumin ratio and prognosis in patients with sepsis-associated acute kidney injury: a retrospective cohort study.Frontiers in medicine · 2026Article
- Protective Effects of Cyclosporin H Against Sepsis-Induced Acute Kidney Injury via Modulation of Fpr1 Signaling and Inhibiting Pyroptosis.Research and reports in urology · 2026Article
- Prognostic value of the advanced lung cancer inflammation index for 28 day mortality in sepsis associated acute kidney injury.Scientific reports · 2025Article
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4 authors.
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Abstract
Sepsis is a major health problem worldwide, and sepsis-associated acute kidney injury (SA-AKI) patients usually experience severe conditions, high mortality, and long length of stay. The predictive value of aggregate index of systemic inflammation (AISI) in the prognosis of several diseases has been documented. This study intends to investigate the association between AISI and mortality in SA-AKI. Data of patients with SA-AKI first admitted to the intensive care unit in 2008-2019 were acquired from the Medical Information Mart for Intensive Care IV (MIMIC-IV). The impact of AISI on 30-/90-/180-d and 1-year mortality in SA-AKI was investigated by Cox proportional hazard regression models, Kaplan-Meier analyses, and restricted cubic spline (RCS) analyses. Moreover, subgroup analyses, stratified by gender, comorbidity, and intervention, were conducted. Totally 9714 SA-AKI patients were included, and they were assigned into a Low AISI Group (AISI < 735.405 × 10
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