Evidence map›Paper›PMID 40817372›Full record

ArticleNature communications2025

Iron-sulfur clusters in SARS-CoV-2 exoribonuclease and methyltransferase complexes: relevance for viral genome proofreading and capping.

Nunziata Maio, Umberto Terranova, Yan Li, J Martin Bollinger, Carsten Krebs, Tracey A Rouault

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nunziata MaioEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA. nunziata.maio@nih.gov.ORCID http://orcid.org/0000-0002-6225-6058
Umberto TerranovaFaculty of Medicine and Health Sciences, The University of Buckingham, Buckingham MK18 1EG & Crewe Campus, Crewe Green Road, Crewe, CW1 5DU, UK.
Yan LiNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Proteomics Core Facility, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0003-3820-5960
J Martin BollingerDepartment of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA.ORCID http://orcid.org/0000-0003-0751-8585
Carsten KrebsDepartment of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA.
Tracey A RouaultEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA. rouault@mail.nih.gov.ORCID http://orcid.org/0000-0003-0062-0245

Funding

Mammalian iron-sulfur cluster biogenesisZIAHD008814 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ROUAULT, TRACEY A. · 2009 to 2025
$17.8M
Mechanisms of Mononuclear non-Heme-Iron EnzymesR35GM127079 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CARSTEN KREBS · 2018 to 2026
$3.8M
Mammalian iron-sulfur cluster biogenesisZ01HD008814 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ROUAULT, TRACEY A. · 2007 to 2008
$1.5M
Intramural NIH HHS Z01 HD008814Intramural NIH HHS ZIA HD008814NIGMS NIH HHS R35 GM127079
6 · The paper itself

Abstract

Coronaviruses rely on a multifunctional replication-transcription complex to ensure genome fidelity and support viral propagation. Within this complex, the nsp14-nsp10 heterodimer possesses 3'-5' exoribonuclease (ExoN) activity, while nsp14 alone functions as an N7-methyltransferase and the nsp16/nsp10 complex completes viral RNA capping via its 2'-O-methyltransferase. Here, we report that nsp14 and nsp10 ligate [Fe

Indexed as

ExoribonucleasesGenome, ViralIron-Sulfur ProteinsMethyltransferasesSARS-CoV-2Viral Nonstructural ProteinsCOVID-19HumansMolecular Dynamics SimulationOxidation-ReductionRNA CapsRNA, ViralViral Regulatory and Accessory ProteinsExoribonucleasesIron-Sulfur ProteinsMethyltransferasesNSP14 protein, SARS-CoV-2NSP16 protein, SARS-CoV-2ORF1ab polyprotein, SARS-CoV-2RNA CapsRNA, ViralViral Nonstructural ProteinsViral Regulatory and Accessory Proteins

Identifiers

PMID40817372
PMCPMC12356973

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.