Evidence map›Paper›PMID 40817338›Full record

ArticleScientific reports2025

Machine learning analysis of pharmaceutical cocrystals solubility parameters in enhancing the drug properties for advanced pharmaceutical manufacturing.

Tareq Nafea Alharby, Bader Huwaimel

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tareq Nafea AlharbyDepartment of Clinical Pharmacy, College of Pharmacy, University of Ha'il, Ha'il, 81442, Saudi Arabia. tn.alharby@uoh.edu.sa.
Bader HuwaimelDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, 81442, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new computational framework based on machine learning was developed for prediction of Hansen solubility parameters in preparation of pharmaceutical cocrystals with improved properties. The models of Kernel Ridge Regression (KRR), Multi-Linear Regression (MLR), and Orthogonal Matching Pursuit (OMP) were optimized in prediction of three Hansen solubility parameters. Each model's performance was assessed via measuring Root Mean Square Error (RMSE), R

Indexed as

Machine LearningAlgorithmsCrystallizationPharmaceutical PreparationsSolubilityPharmaceutical PreparationsIntelligence computationMachine learningPharmaceutical cocrystalSolubility

Identifiers

PMID40817338
PMCPMC12356857

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.