ArticleNature communications2025
Gene transcription, neurotransmitter, and neurocognition signatures of brain structural-functional coupling variability.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Bridging molecules and connectome: network biomarkers guided by neurotransmitter architecture in major depressive disorder.Translational psychiatry · 2026Article
- Functional gradient variations in different neuroticism levels and its correlation with cell type-specific transcriptional signatures.Social cognitive and affective neuroscience · 2026Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Genetic contribution to intrinsic functional connectivity underlying general intelligence: evidence from adult twin study.Brain communications · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
The relationship between brain structure and function, known as structural-functional coupling (SFC), is highly dynamic. However, the temporal variability of this relationship, referring to the fluctuating extent to which functional profiles interact with anatomy over time, remains poorly elucidated. Here, we propose a framework to quantify SFC temporal variability and determine its neurocognitive map, genetic architecture, and neurochemical basis in 1206 healthy human participants. Results reveal regional heterogeneity in SFC variability and a composite emotion dimension co-varying with variability patterns involving the dorsal attention, somatomotor, and visual networks. The transcriptomic signatures of SFC variability are enriched in synapse- and cell cycle-related biological processes and implicated in emotion-related disorders. Moreover, regional densities of serotonin, glutamate, γ-aminobutyric acid, and opioid systems are predictive of SFC variability across the cortex. Collectively, SFC variability mapping provides a biologically plausible framework for understanding how SFC fluctuates over time to support macroscale neurocognitive specialization.
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Registered trials
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